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Art. -Nr.: HY-139499

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Sudemycin D6

Sudemycin D6 is a pre-mRNA splicing modulator with potent antitumour activity. Sudemycin D6 changes splice site usage of the DUSP11 and SRRM1 pre-mRNA. Sudemycin D6 reduces survival and alters cell cycle in haematopoietic cells expressing mutant U2AF1. Sudemycin D6 attenuates mutant U2AF1-induced haematopoietic progenitor cell expansion in U2AF1(S34F) transgenic mice. Sudemycin D6 can be used for cancer research.

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CAS. Nr.: 1510837-67-8
Formel: C₂₇H₄₂N₂O₅
Molecular Weight:474.63

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Sudemycin D6 Chemical Structure

CAS. Nr.: 1510837-67-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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- Cellular Effect
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

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Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	50 nM Compound: 3, sudemycin D6	Cytotoxicity against human HeLa cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human HeLa cells after 72 hrs by CellTiter-Glo assay	[PMID: 24325474]
JeKo-1	IC₅₀	22 nM Compound: 3, sudemycin D6	Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human JeKo1 cells after 72 hrs by CellTiter-Glo assay	[PMID: 24325474]
PC-3	IC₅₀	142 nM Compound: 3, sudemycin D6	Cytotoxicity against human PC3 cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human PC3 cells after 72 hrs by CellTiter-Glo assay	[PMID: 24325474]
SK-MEL-2	IC₅₀	39 nM Compound: 3, sudemycin D6	Cytotoxicity against human SK-MEL-2 cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human SK-MEL-2 cells after 72 hrs by CellTiter-Glo assay	[PMID: 24325474]
SK-N-AS	IC₅₀	81 nM Compound: 3, sudemycin D6	Cytotoxicity against human SK-N-AS cells after 72 hrs by CellTiter-Glo assay Cytotoxicity against human SK-N-AS cells after 72 hrs by CellTiter-Glo assay	[PMID: 24325474]

Chemical Information

CAS. Nr. 1510837-67-8
Molecular Weight 474.63
Formel C₂₇H₄₂N₂O₅
SMILES

CNC(O[C@@H](C)/C=C\C(N[C@@H](CC1)CC[C@@H]1C/C=C(C)/C=C/[C@@H]2C[C@@]3(CC(C)(O2)C)CO3)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shirai CL, et al. Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome. Nat Commun. 2017 Jan 9;8:14060. [Content Brief]

[2]. Thurman M, et al. Changes in Alternative Splicing as Pharmacodynamic Markers for Sudemycin D6. Biomark Insights. 2017 Sep 12;12:1177271917730557. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Sudemycin D6

Alle DNA/RNA Synthesis Isoform-spezifische Produkte anzeigen

Biologische Aktivität

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Sudemycin D6 Related Classifications

HY-139499 Related Classifications