Tylogenin
Tylogenin is a Na+/K+ ATPase inhibitor with an IC50 of 93.3 μM against rabbit-derived targets. Tylogenin inhibits antigen-induced mediator release from rabbit basophils and IgE-dependent histamine release from human leukocytes. Tylogenin exhibits antiallergic activity. Tylogenin can be used in research related to allergic diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 135247-46-0
- Formel: C28H38O10
- Molecular Weight:534.60
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Tylogenin (1-300 μM; 15-120 min) exhibits time-dependent inhibition of antigen-induced serotonin release from sensitized rabbit basophils in the BDSR assay, with an IC50 of 38.90 μM after 120 min of incubation, and the inhibition rate reaches 92% at a concentration of 300 μM following 120 min of incubation[1].
Tylogenin (1-300 μM; 4 h) inhibits antigen-induced Histamine (HY-B1204) release from leukocytes of atopic individuals in the LDHR assay, with an IC50 of 48.98 μM[1].
Tylogenin (5-2000 μM; 1 h) inhibits Na+/K+ ATPase activity in rabbit renal cortical basolateral membrane vesicles, with an IC50 of 93.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 135247-46-0
-
Molecular Weight 534.60
-
Formel C28H38O10
-
SMILES
C[C@]12[C@@]([C@H](C(CC2)=O)OC(C)=O)([H])[C@H](C[C@]3([H])[C@]1([H])CC[C@@]([C@@H]3OC(C)=O)(C([C@@](C)(O4)OC)=CC4=O)C)OC(C)=O
-
Structure Classification
-
Initial Source
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Gnabre, Jean-Noel. Antiallergic activity of Tylophora sylvatica. The University of Arizona.
[2]. Gnabre JN, et al. Antiallergic activity of tylogenin, a novel steroidal compound from Tylophora sylvatica. International journal of immunopharmacology. 1994 Aug;16(8):641-50. [Content Brief]
[3]. Gnabre JN, et al. Tylophora compounds as Na+/K(+)-ATPase inhibitors. Gen Pharmacol. 1993 Sep;24(5):1107-13. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Tylogenin Related Classifications
HY-183389 Related Classifications
Powered by Bioz