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Art. -Nr.: HY-P99380

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Biologically Validated

Zanidatamab

Name: Zanidatamab
Brand: MedChemExpress
SKU: HY-P99380
Price: 430.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ZW 25; ZW-49 Antibody)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 98.56%
CAS. Nr.: 2169946-15-8
Molecular Weight:124.65kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zanidatamab Chemical Structure

CAS. Nr.: 2169946-15-8

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Preis

Verfügbarkeit

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Publications Citing Use of MedChemExpress (MCE) Zanidatamab

MAbs. 2024 Jan-Dec;16(1):2412881. [Abstract]

Customer Validation & Images

Cell Proliferation/Viability AssayWB

Cell Proliferation/Viability Assay
WB

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity^[1].

Isotype

half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[1]

HER2

Alle EGFR Isoform-spezifische Produkte anzeigen :

In Vitro

Zanidatamab (ZW25) has low nM binding affinity (0.9-16 nM) to recombinant HER2 and to cultured cancer cells with a range of HER2 expression^[1].
Zanidatamab inhibits the growth of human cancer cell lines with a wide range of HER2 expression (5-54% inhibition depending on the cell line), and inhibits ligand-mediated tumor cell proliferation^[1].
Zanidatamab elicits concentration-dependent ADCC at nM potency (0.05-64 nM) with maximal lysis up to 52% on TNBC cell lines expressing HER2 and exhibits synergy and additivity with multiple chemotherapeutic agents including platins, taxanes, microtubule inhibitors, and DNA synthesis inhibitors in various HER2 expressing tumor cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Zanidatamab (ZW25) induces significant tumor regressions, exhibiting 307% tumor growth inhibition relative to hIgG control and a 70% complete regression rate^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

2064 [NCBI]

Accession

P04626

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Loaded Zanidatamab on AHC2 biosensor, can bind HER2/CD340 Protein, Human (S310Y, HEK293, His, HY-P78680) with an affinity constant of 7.956E-11 M as determined in BLI assay.
Immobilized Zanidatamab can bind Human Her2/ERBB2 Protein (ECD, His Tag). The EC₅₀ for this effect is 3.09 ng/mL.

Chemical Information

CAS. Nr. 2169946-15-8
Appearance Liquid
Molecular Weight 124.65kDa
Color Colorless to light yellow
SMILES

[Zanidatamab]
Synonyms

ZW 25; ZW-49 Antibody
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

All Cell Proliferation/Viability AssayWB

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Journal Impact Factor

MAbs

Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo. [Abstract]

2024 Jan-Dec;16(1):2412881. PMID: 39381966

Zanidatamab purchased from MedChemExpress. Usage Cited in: MAbs. 2024 Jan-Dec;16(1):2412881. [Abstract]

Head-to-head comparison of KJ015, Zanidatamab (0.01-100 μg/mL, 120 h), and Anbenitamab in MDA-MB-175. All assays were repeated twice.

Zanidatamab purchased from MedChemExpress. Usage Cited in: MAbs. 2024 Jan-Dec;16(1):2412881. [Abstract]

Immunoblots of cell lysates from SK-Br-3 and NCI-N87 cells treated with IgG, Trastuzumab, Pertuzumab, tras+pert, or KJ015 at a final concentration of 50 nM for 24 h. Extra groups of anbenitamab and zanidatamab were added at the same concentration in MDA-MB-175 cells. Actin served as the loading control. T: trastuzumab, P: pertuzumab, T+P: tras+pert, Anbe: anbenitamab, Zani: zanidatamab.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Weisser N, et, al. Preclinical development of a novel biparatopic HER2 antibody with activity in low to high HER2 expressing cancers. Cancer Res. 2017:77 (13).

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Zanidatamab

1 Cited Publications

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Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise

1/16

half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3
1/16

Loaded Zanidatamab on AHC2 biosensor, can bind HER2/CD340 Protein, Human (S310Y, HEK293, His, HY-P78680) with an affinity constant of 7.956E-11 M as determined in BLI assay.
1/16

Immobilized Zanidatamab can bind Human Her2/ERBB2 Protein (ECD, His Tag). The EC₅₀ for this effect is 3.09 ng/mL.
1/16

Zanidatamab purchased from MedChemExpress. Usage Cited in: MAbs. 2024 Jan-Dec;16(1):2412881. [Abstract]

Customer Validation
Head-to-head comparison of KJ015, Zanidatamab (0.01-100 μg/mL, 120 h), and Anbenitamab in MDA-MB-175. All assays were repeated twice.
1/16

Zanidatamab purchased from MedChemExpress. Usage Cited in: MAbs. 2024 Jan-Dec;16(1):2412881. [Abstract]

Customer Validation
Immunoblots of cell lysates from SK-Br-3 and NCI-N87 cells treated with IgG, Trastuzumab, Pertuzumab, tras+pert, or KJ015 at a final concentration of 50 nM for 24 h. Extra groups of anbenitamab and zanidatamab were added at the same concentration in MDA-MB-175 cells. Actin served as the loading control. T: trastuzumab, P: pertuzumab, T+P: tras+pert, Anbe: anbenitamab, Zani: zanidatamab.
1/16

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Zanidatamab

Bradford Protein Assay Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Cell-ATP Viability Detection Kit

Protein A Agarose

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Publications Citing Use of MedChemExpress (MCE) Zanidatamab

Alle EGFR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

Isotype

Recommend Isotype Controls

Species Reactivity

IC50 & Target

In Vitro

In Vivo

Clinical Trial

Gene ID

Accession

Conjugated

Reconsititution

Format

Anwendung

Verified Bioactivity

Chemical Information

Publications (1)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Zanidatamab Related Classifications

HY-P99380 Related Classifications

Bioz

Keywords

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