PLK3-IN-1
PLK3-IN-1 is a selective Polo-like kinase 3 (PLK3) inhibitor with a human PLK3 IC50 of 5 nM. PLK3-IN-1 can be used for cancer research.
For research use only. We do not sell to patients.
- Formula: C27H29FN8O
- Molecular Weight:500.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
PLK3-IN-1 (Compound 9) potently inhibits purified PLK3 with an IC50 of 0.005 μM, and exhibits 1000-fold selectivity over PLK1 and 60-fold selectivity over PLK2 in a biochemical kinase inhibition assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 500.57
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Formula C27H29FN8O
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SMILES
CN1CCC[C@H](C1)C2=CNC3=CC=C(C=C32)NC4=NC=C(C(N5CCN(C(C5)=O)C6=CC=CC=N6)=N4)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PLK3-IN-1 Related Classifications
HY-183965 Related Classifications
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