Explore conserved antiviral mechanisms across mammals and bacteria, from virus recognition and immune signaling to metabolic defense and gasdermin-mediated cell death, and their implications for innate immune evolution.
Learning Centers
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Conserved Antiviral Immunity Across Domains of Life: From Pathogen Sensing to Effector Responses -
Mitochondrial Control of Cellular Senescence: Quality Control, Innate Immunity, and Metabolic–Epigenetic Regulation Explore how mitochondrial quality control, inflammatory signaling, and metabolic–epigenetic reprogramming regulate cellular senescence and the SASP, along with strategies to restore mitochondrial homeostasis. -
Beyond One Brake: How Tumours Dynamically Rewire the Immune Checkpoint Network Explore the mechanisms of tumor immune evasion, dynamic checkpoint regulation, and the evolution of mechanism-driven combinations and patient stratification. -
Evolution of PCSK9 Inhibitors Modalities: From Monoclonal Antibodies to Oral Macrocyclic Peptides Review the biological basis of PCSK9, key therapeutic modalities, cardiovascular evidence, and future directions, including insights from the CORALreef clinical program.
