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Cat. No.: HY-N1107

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Uzarigenin

(Synonyms: NSC 119993; NSC 277290; Odorigeni)

Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively.

For research use only. We do not sell to patients.

CAS No.: 466-09-1
Formula: C₂₃H₃₄O₄
Molecular Weight:374.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Uzarigenin Chemical Structure

CAS No.: 466-09-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	3.9 μM Compound: 1	Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human BT-549 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32649211]
Calu-1	IC₅₀	8 μM Compound: 23	Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay Antiproliferative activity against human Calu1 cells after 72 hrs by MTT assay	[PMID: 30629433]
HeLa	IC₅₀	3 μM Compound: 23	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 30629433]
Hs-578T	IC₅₀	3.6 μM Compound: 1	Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32649211]
MCF7	IC₅₀	6 μM Compound: 23	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30629433]
MDA-MB-231	IC₅₀	>30 μM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 32649211]
PC-3	IC₅₀	0.3 μM Compound: 23	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 30629433]
U-251	IC₅₀	6 μM Compound: 23	Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay Antiproliferative activity against human U251MG cells after 72 hrs by MTT assay	[PMID: 30629433]

Chemical Information

CAS No. 466-09-1
Molecular Weight 374.51
Formula C₂₃H₃₄O₄
SMILES

O=C1OCC([C@H]2CC[C@]3(O)[C@]4([H])CC[C@@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=C1
Synonyms

NSC 119993; NSC 277290; Odorigeni
Structure Classification
- Steroids
- Cardiacglycosides
Initial Source
- Plants
- Apocynaceae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hosseini SH, et al. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa. J Nat Prod. 2019 Jan 25;82(1):74-79. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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