Bapotulimab
Based on 1 Customer Validation
Bapotulimab (BAY-1905254) is a fully human IgG2 antibody targeting immunoglobulin-like domain containing receptor 2 (ILDR2). Bapotulimab has antitumor and immunosuppressive effects.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 2359413-58-2
- Molecular Weight:144.98 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
ILDR2
In Vitro
Bapotulimab blocks the immunosuppressive effects of ILDR2 on T-cell activation. Bapotulimab is mouse/human cross-reactive, as ILDR2 has a 98% sequence identity between the extracellular domains of human and murine orthologs[1].
Bapotulimab (BAY-1905254; 5, 25, 100, or 500 ng/mL) promotes T-cell activation in vitro and enhance antigen-specific T-cell proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8- to 12-week-old CD45.1-expressing C57BL/6 wild-type mice injected with OT-I transgenic T cells[1]
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Dosage:10 mg/kg
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Administration:i.p.; on days 1 and 4
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Result:Showed significantly increased antigen-specific T-cell proliferation and cytotoxicity.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG2 kappa
Application
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2359413-58-2
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Appearance Liquid
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Molecular Weight 144.98 kDa
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Color Colorless to light yellow
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SMILES
[Bapotulimab]
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Synonyms
BAY-1905254
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bapotulimab Related Classifications
HY-P99460 Related Classifications
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