2. PROTAC
  3. PROTAC Linkers
  4. Benzaldehyde-PEG4-azide

Benzaldehyde-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzaldehyde-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Benzaldehyde-PEG4-azide Chemical Structure

Benzaldehyde-PEG4-azide Chemical Structure

CAS No. : 1151451-77-2

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Based on 1 publication(s) in Google Scholar

Benzaldehyde-PEG4-azide Related Antibodies

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Description

Benzaldehyde-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Benzaldehyde-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benzaldehyde-PEG4-azide Related Antibodies
Molecular Weight

323.34

Formula

C15H21N3O5
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=CC1=CC=C(OCCOCCOCCOCCN=[N+]=[N-])C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (309.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0927 mL 15.4636 mL 30.9272 mL
5 mM 0.6185 mL 3.0927 mL 6.1854 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (240 KB) HNMR (133 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0927 mL 15.4636 mL 30.9272 mL 77.3180 mL
5 mM 0.6185 mL 3.0927 mL 6.1854 mL 15.4636 mL
10 mM 0.3093 mL 1.5464 mL 3.0927 mL 7.7318 mL
15 mM 0.2062 mL 1.0309 mL 2.0618 mL 5.1545 mL
20 mM 0.1546 mL 0.7732 mL 1.5464 mL 3.8659 mL
25 mM 0.1237 mL 0.6185 mL 1.2371 mL 3.0927 mL
30 mM 0.1031 mL 0.5155 mL 1.0309 mL 2.5773 mL
40 mM 0.0773 mL 0.3866 mL 0.7732 mL 1.9329 mL
50 mM 0.0619 mL 0.3093 mL 0.6185 mL 1.5464 mL
60 mM 0.0515 mL 0.2577 mL 0.5155 mL 1.2886 mL
80 mM 0.0387 mL 0.1933 mL 0.3866 mL 0.9665 mL
100 mM 0.0309 mL 0.1546 mL 0.3093 mL 0.7732 mL
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Benzaldehyde-PEG4-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzaldehyde-PEG4-azide1151451-77-2PROTAC LinkersInhibitorinhibitorinhibit

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