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Cat. No.: HY-162621

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BET-IN-25

BET-IN-25 (compound 7) is an oral bioactive inhibitor of bromodomain (BD1) and BD2, with the IC₅₀s of 0.18 μM and 9.2 μM, respectively.

For research use only. We do not sell to patients.

Formula: C₁₉H₂₅N₅O₄S
Molecular Weight:419.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

BET-IN-25 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BET-IN-25 (compound 7) is an oral bioactive inhibitor of bromodomain (BD1) and BD2, with the IC₅₀s of 0.18 μM and 9.2 μM, respectively^[1].

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Chemical Information

Molecular Weight 419.50
Formula C₁₉H₂₅N₅O₄S
SMILES

CN1C=C(C2=NN(C)C=C2)C(OC(CN3CCN(S(=O)(C)=O)C[C@H]3C)=C4)=C4C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shuichi Hagihara, et al. Discovery of a potent, orally available furopyridine derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor. Bioorg Med Chem Lett. 2024 Sep 1:109:129848. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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Chemical Information
Purity & Documentation
References

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BET-IN-25

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Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BET-IN-25 Related Classifications

HY-162621 Related Classifications