2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG2-CH2CH2N3

Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG2-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Biotin-PEG2-CH2CH2N3 Chemical Structure

Biotin-PEG2-CH2CH2N3 Chemical Structure

CAS No. : 945633-30-7

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25 mg USD 40 In-stock
50 mg USD 63 In-stock
100 mg USD 105 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-PEG2-CH2CH2N3 Related Antibodies

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG2-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG2-CH2CH2N3 Related Antibodies
Molecular Weight

400.50

Formula

C16H28N6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCN=[N+]=[N-])CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (249.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4969 mL 12.4844 mL 24.9688 mL
5 mM 0.4994 mL 2.4969 mL 4.9938 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4969 mL 12.4844 mL 24.9688 mL 62.4220 mL
5 mM 0.4994 mL 2.4969 mL 4.9938 mL 12.4844 mL
10 mM 0.2497 mL 1.2484 mL 2.4969 mL 6.2422 mL
15 mM 0.1665 mL 0.8323 mL 1.6646 mL 4.1615 mL
20 mM 0.1248 mL 0.6242 mL 1.2484 mL 3.1211 mL
25 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4969 mL
30 mM 0.0832 mL 0.4161 mL 0.8323 mL 2.0807 mL
40 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5605 mL
50 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2484 mL
60 mM 0.0416 mL 0.2081 mL 0.4161 mL 1.0404 mL
80 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
100 mM 0.0250 mL 0.1248 mL 0.2497 mL 0.6242 mL
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Biotin-PEG2-CH2CH2N3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG2-CH2CH2N3945633-30-7PROTAC LinkersInhibitorinhibitorinhibit

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