BMS-345541 hydrochloride (Standard)
BMS-345541 hydrochloride (Standard) is the analytical standard of BMS-345541 hydrochloride (HY-10518). This product is intended for research and analytical applications. BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
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- Pureté : 0%
- CAS No.: 547757-23-3
- Formule: C14H18ClN5
- Masse moléculaire:291.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-10518
BMS-345541 hydrochlorideIKK-1/IKK-2 Inhibitor -
HY-10172
IMD-0354IKKβ Inhibitor -
HY-15473
MLN120BIKKβ Inhibitor -
HY-13802
SC-514IKK Inhibitor -
HY-10519
BMS-345541IKK-1/IKK-2 Inhibitor -
HY-10074
TPCA-1IKK-2 Inhibitor -
HY-12453
TBK1/IKKε-IN-2TBK1/IKKε Inhibitor -
HY-13060
ACHP HydrochlorideIKKβ Inhibitor -
HY-10257
BAY 11-7085NF-κB Activation Inhibitor -
HY-13453
BAY 11-7082IκBα/NF-κB Inhibitor -
HY-N0551
WedelolactoneCaspase-11 And 5-Lox Inhibitor -
HY-13687
IKK 16IKK Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 547757-23-3
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Masse moléculaire 291.78
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Formule C14H18ClN5
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SMILES
CC1=CN=C2C(NCCN)=NC3=CC=C(C=C3N21)C.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456. [Content Brief]
[2]. Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960. [Content Brief]
[3]. MacMaster JF, et al. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res, 2003, 52(12), 508-511. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-345541 hydrochloride (Standard) Related Classifications
HY-10518R Related Classifications
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