1. Protein Tyrosine Kinase/RTK
  2. c-Fms
  3. c-Fms-IN-6

c-Fms-IN-6 

Cat. No.: HY-111947
Handling Instructions

c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases.

For research use only. We do not sell to patients.

c-Fms-IN-6 Chemical Structure

c-Fms-IN-6 Chemical Structure

CAS No. : 1628574-81-1

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Description

c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases[1].

IC50 & Target

IC50: ≤10 nM (c-FMS)[1]

In Vitro

c-Fms-IN-6 (Example 38) shows inhibitory activity against M-NFS-60 cell proliferation, with an IC50 in the range of 0.01 μM to 0.1 μM[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

419.48

Formula

C₂₂H₂₅N₇O₂

CAS No.

1628574-81-1

SMILES

O=C1N(C2=NC(C)=C(OC3=CC(C4=CN(CC)N=C4)=NC=C3)C=C2)N=C(C(C)(C)C)N1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
c-Fms-IN-6
Cat. No.:
HY-111947
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c-Fms-IN-6

Cat. No.: HY-111947