c-Met-IN-9
c-Met-IN-9, a 4-phenoxypyridine derivative, is a c-Met kinas inhibitor with an IC50 of 12 nM. c-Met-IN-9 induces cells apoptosis, and has antitumor activities.
For research use only. We do not sell to patients.
- CAS No.: 2760326-29-0
- Formula: C25H19F2N5O3
- Molecular Weight:475.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
c-Met-IN-9 (Compound T14) shows remarkable antiproliferative activities against MKN-45, A549 and H460 cell lines with IC50 values of 0.64 μM, 1.92 μM and 2.68 μM, respectively[1].
c-Met-IN-9 could inhibit cells colony formation, induce cells apoptosis, and inhibit cells motility[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2760326-29-0
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Molecular Weight 475.45
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Formula C25H19F2N5O3
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SMILES
O=C(C1=CN(C2=CC=C(F)C=C2)C=N1)NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=C4)C(F)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
c-Met-IN-9 Related Classifications
HY-115937 Related Classifications
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