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Cat. No.: HY-P11552

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(Asp-Ser-Ser)6

Name: (Asp-Ser-Ser)6
Brand: MedChemExpress
SKU: HY-P11552
Price: 200.00 USD
Availability: PreOrder

(Synonyms: (DSS)6)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

(Asp-Ser-Ser)6 ((DSS)6) is a synthetic bone-targeting peptide. (Asp-Ser-Ser)6 binds to hydroxyapatite and Ca²⁺ in mineralized tissues, preferentially binds to low-crystallinity hydroxyapatite in bone-forming regions, and localizes conjugated liposome-siRNA complexes to adjacent osteogenic areas. (Asp-Ser-Ser)6 can be used in research on osteoporosis and cranial defects.

For research use only. We do not sell to patients.

CAS No.: 929906-72-9
Formula: C₆₀H₉₂N₁₈O₄₃
Molecular Weight:1753.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Asp-Ser-Ser)6 Chemical Structure

CAS No.: 929906-72-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
Publications (1)
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Biological Activity

Description

In Vitro

(Asp-Ser-Ser)6 ((DSS)6) (12 mg-10 h) is successfully synthesized into DSPE-PEG-(DSS)₆^[1] through amidation reaction with DSPE-PEG-COOH.
(Asp-Ser-Ser)6 (2 h) maintains a spherical, intact morphology and a size range similar to that of natural ApoEVs after DSPE-PEG-(DSS)₆ membrane modification^[1].
(Asp-Ser-Ser)6 (7-28 days) increases ALP and RUNX2 expression and mineralized nodule formation in OVX-derived BMSCs after osteogenic induction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 929906-72-9
Molecular Weight 1753.47
Formula C₆₀H₉₂N₁₈O₄₃
Synonyms

(DSS)6
Sequence

Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser
Sequence Shortening

DSSDSSDSSDSSDSSDSS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Genes (Basel)

2026 Sep 19;17(9):1148. PMID: 42793042

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gui L, et al. Bone-Targeting Peptide and RNF146 Modified Apoptotic Extracellular Vesicles Alleviate Osteoporosis. International journal of nanomedicine. 2024;19:471-488. [Content Brief]

[2]. Gu Y, et al. Vitexin Alleviates Knee Osteoarthritis-Associated Cartilage Damage Associated with F3 Modulation. Genes. 2026 Sep 19;17(9):1148.

[3]. Xu G, et al. The construction of a novel xenograft bovine bone scaffold, (DSS)6-liposome/CKIP-1 siRNA/calcine bone and its osteogenesis evaluation on skull defect in rats. J Orthop Translat. 2021 Mar 2;28:74-82.

[4]. Liu J, et al. Bi-directionally selective bone targeting delivery for anabolic and antiresorptive drugs: a novel combined therapy for osteoporosis?. Medical hypotheses. 2014 Dec;83(6):694-6. [Content Brief]

[5]. Si K, et al. Binding mechanism and bioavailability of a novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer) calcium complex. Food chemistry. 2023 Mar 15;404(Pt A):134567.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(Asp-Ser-Ser)6

1 Cited Publications

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Biological Activity
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Chemical Information
Publications (1)
Purity & Documentation
References

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(Asp-Ser-Ser)6

Publications Citing Use of MedChemExpress (MCE) (Asp-Ser-Ser)6