BCN-DOTA
Based on 1 Customer Validation
BCN-DOTA is a cyclooctyne-linked DOTA chelator. BCN-DOTA integrates BCN and DOTA, enabling conjugation with azide-functionalized groups via the click chemistry properties of BCN, while binding to metal ions through the coordination capacity of DOTA. BCN-DOTA can serve as a radionuclide-drug conjugate (RDC) to target specific biomolecules, cells or tissues after radiolabeling with zirconium-89. BCN-DOTA is applicable to research related to PET imaging and targeted therapy.
For research use only. We do not sell to patients.
- CAS No.: 2565792-45-0
- Formula: C29H46N6O9
- Molecular Weight:622.71
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
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RDC Bifunctional Chelator |
BCN-DOTA does not react with SMNPs assembled from amp-azide monomers, presumably due to the azide group's lack of solvent accessibility within the SMNPs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2565792-45-0
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Appearance Solid
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Molecular Weight 622.71
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Formula C29H46N6O9
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Color White to off-white
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SMILES
O=C(NCCNC(OC[C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])=O)CN3CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : ≥ 100 mg/mL (160.59 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6059 mL | 8.0294 mL | 16.0588 mL | 40.1471 mL |
| 5 mM | 0.3212 mL | 1.6059 mL | 3.2118 mL | 8.0294 mL | |
| 10 mM | 0.1606 mL | 0.8029 mL | 1.6059 mL | 4.0147 mL | |
| 15 mM | 0.1071 mL | 0.5353 mL | 1.0706 mL | 2.6765 mL | |
| 20 mM | 0.0803 mL | 0.4015 mL | 0.8029 mL | 2.0074 mL | |
| 25 mM | 0.0642 mL | 0.3212 mL | 0.6424 mL | 1.6059 mL | |
| 30 mM | 0.0535 mL | 0.2676 mL | 0.5353 mL | 1.3382 mL | |
| 40 mM | 0.0401 mL | 0.2007 mL | 0.4015 mL | 1.0037 mL | |
| 50 mM | 0.0321 mL | 0.1606 mL | 0.3212 mL | 0.8029 mL | |
| 60 mM | 0.0268 mL | 0.1338 mL | 0.2676 mL | 0.6691 mL | |
| 80 mM | 0.0201 mL | 0.1004 mL | 0.2007 mL | 0.5018 mL | |
| 100 mM | 0.0161 mL | 0.0803 mL | 0.1606 mL | 0.4015 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BCN-DOTA Related Classifications
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