CDK5 - cyclin dependent kinase 5 Gene

Also Known as LIS7; PSSALRE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1020

About CDK5

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:151,053,815-151,057,897 (from NCBI)

This gene has 5 transcripts (splice variants), 167 orthologues, 26 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 18.5), adrenal (RPKM 6.8) and 25 other tissues.

Summary

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike Other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and Apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

CDK5 Products (2)

mRNA	Protein	Name
NM_004935.4	NP_004926.1	cyclin-dependent kinase 5 isoform 1
NM_001164410.3	NP_001157882.1	cyclin-dependent kinase 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8090221	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	20357208	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20357208	GOA
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	24548080	GOA
involved in oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	18042622	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21145489	GOA
involved in phosphorylation	IDA IDA: Inferred from direct assay	20357208	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	16039528	GOA
part of protein kinase 5 complex	IPI IPI: Inferred from physical interaction	15689152	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK5 Protein Structure

Pkinase

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 5	TPKII catalytic subunit cell division protein kinase 5 cyclin-dependent-like kinase 5 epididymis secretory sperm binding protein protein kinase CDK5 splicing serine/threonine-protein kinase PSSALRE tau protein kinase II catalytic subunit

CDK5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK5	Q00535	CCNI	Homo sapiens	Q14094	Y2H Prey Pooling	32296183
Intra	CDK5	Q00535	CCNI	Homo sapiens	Q14094	Y2H Array	32296183
Intra	CDK5	Q00535	CCNI	Homo sapiens	Q14094	Validated Y2H	32296183
Intra	CDK5	Q00535	CCNI	Homo sapiens	Q14094	Anti Tag CoIP	25852190
Intra	CDK5	Q00535	SPDYE4	Homo sapiens	A6NLX3	Y2H Array	32296183
Intra	CDK5	Q00535	SPDYE4	Homo sapiens	A6NLX3	Y2H Prey Pooling	32296183
Intra	CDK5	Q00535	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	CDK5	Q00535	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	CDK5	Q00535	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	CDK5	Q00535	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CDK5	Q00535	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CDK5	Q00535	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CDK5	Q00535	TBP	Homo sapiens	P20226	Validated Y2H	32814053
Intra	CDK5	Q00535	TBP	Homo sapiens	P20226	Y2H Array	32814053
Intra	CDK5	Q00535	TBP	Homo sapiens	P20226	Y2H Pooling	32814053
Intra	CDK5	Q00535	CCND3	Homo sapiens	P30281	TAP	23602568
Intra	CDK5	Q00535	CCND3	Homo sapiens	P30281	TAP	23455922
Intra	CDK5	Q00535	CCND3	Homo sapiens	P30281	Y2H Array	32296183
Intra	CDK5	Q00535	CCND3	Homo sapiens	P30281	Y2H Prey Pooling	32296183
Intra	CDK5	Q00535	CDKN1A	Homo sapiens	P38936	TAP	23455922
Intra	CDK5	Q00535	CDKN1A	Homo sapiens	P38936	SPR	15890360
Intra	CDK5	Q00535	CDKN1A	Homo sapiens	P38936	TAP	23602568
Intra	CDK5	Q00535	CCNC	Homo sapiens	P24863	Anti Tag CoIP	25852190
Intra	CDK5	Q00535	PPIA	Homo sapiens	P62937	Y2H Pooling	32814053
Intra	CDK5	Q00535	PPIA	Homo sapiens	P62937	Validated Y2H	32814053
Intra	CDK5	Q00535	PPIA	Homo sapiens	P62937	Y2H Array	32814053
Intra	CDK5	Q00535	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	25852190
Intra	CDK5	Q00535	CCNB1	Homo sapiens	P14635	TAP	23602568
Intra	CDK5	Q00535	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	33961781
Intra	CDK5	Q00535	CCNB1	Homo sapiens	P14635	TAP	23455922
Intra	CDK5	Q00535	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	28514442
Intra	CDK5	Q00535	CCNB1	Homo sapiens	P14635	Pull Down	32707033
Intra	CDK5	Q00535	CCNB1	Homo sapiens	P14635	Anti Tag CoIP	35271311
Intra	CDK5	Q00535	CDKN1B	Homo sapiens	P46527	Footprinting	15890360
Intra	CDK5	Q00535	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	25852190
Intra	CDK5	Q00535	CDKN1B	Homo sapiens	P46527	TAP	23602568
Intra	CDK5	Q00535	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	33961781
Intra	CDK5	Q00535	CDKN1B	Homo sapiens	P46527	TAP	23455922
Intra	CDK5	Q00535	CDKN1B	Homo sapiens	P46527	Anti Tag CoIP	28514442
Intra	CDK5	Q00535	CDKN1B	Homo sapiens	P46527	Pull Down	32707033
Intra	CDK5	Q00535	CABLES1	Homo sapiens	Q8TDN4	Anti Tag CoIP	33961781
Intra	CDK5	Q00535	CABLES1	Homo sapiens	Q8TDN4	TAP	23602568
Intra	CDK5	Q00535	CABLES1	Homo sapiens	Q8TDN4	TAP	23455922
Intra	CDK5	Q00535	CABLES1	Homo sapiens	Q8TDN4	Anti Tag CoIP	28514442
Intra	CDK5	Q00535	CABLES1	Homo sapiens	Q8TDN4	Pull Down	32707033
Intra	CDK5	Q00535	CABLES1	Homo sapiens	Q8TDN4	Anti Bait CoIP	20559324
Intra	CDK5	Q00535	CABLES1	Homo sapiens	Q8TDN4	Anti Tag CoIP	25852190
Intra	CDK5	Q00535	SPDYA	Homo sapiens	Q5MJ70	Y2H Prey Pooling	32296183
Intra	CDK5	Q00535	SPDYA	Homo sapiens	Q5MJ70	Validated Y2H	32296183
Intra	CDK5	Q00535	SPDYA	Homo sapiens	Q5MJ70	Y2H Array	32296183
Intra	CDK5	Q00535	CDK5R1	Homo sapiens	Q15078	TAP	23602568
Intra	CDK5	Q00535	CDK5R1	Homo sapiens	Q15078	Anti Tag CoIP	33961781
Intra	CDK5	Q00535	CDK5R1	Homo sapiens	Q15078	Protein Kinase Assay	14521924
Intra	CDK5	Q00535	CDK5R1	Homo sapiens	Q15078	Pull Down	20133653
Intra	CDK5	Q00535	CDK5R1	Homo sapiens	Q15078	X-Ray Diffraction	15689152
Intra	CDK5	Q00535	CDK5R1	Homo sapiens	Q15078	Ion Exchange Chrom	20133653
Intra	CDK5	Q00535	CDK5R1	Homo sapiens	Q15078	Anti Bait CoIP	21220307
Intra	CDK5	Q00535	HOOK1	Homo sapiens	Q9UJC3	Validated Y2H	32814053
Intra	CDK5	Q00535	HOOK1	Homo sapiens	Q9UJC3	Y2H Array	32814053
Intra	CDK5	Q00535	HOOK1	Homo sapiens	Q9UJC3	Y2H Pooling	32814053
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	TAP	23602568
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Validated Y2H	27107012
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Y2H Prey Pooling	25416956
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Y2H Prey Pooling	26871637
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	TAP	23455922
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Y2H Prey Pooling	32296183
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Validated Y2H	26871637
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Pull Down	32707033
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Y2H Array	26871637
Intra	CDK5	Q00535	CCND2	Homo sapiens	P30279	Y2H Array	32296183
Intra	CDK5	Q00535	PPARG	Homo sapiens	P37231-2	Anti Bait CoIP	22078880
Intra	CDK5	Q00535	PPARG	Homo sapiens	P37231-2	Y2H	22078880

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDK5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72298	CDK5 Protein, Human (P.pastoris, His)	Q00535 (M1-P292)	≥ 90%, as determined by reducing SDS-PAGE.

CDK5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80078	CDK5 Antibody (YA512)	WB, IHC-P, FC, IP	Human, Mouse, Rat
HY-P80613	CDK5 Antibody (YA796)	WB, ICC/IF	Human, Mouse, Rat, Monkey
HY-P84450	CDK5 Antibody (YA4147)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
HY-P84450A	CDK5 Antibody (YA4147)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
HY-P85533	CDK5(N-term) Antibody (YA5225)	WB, ICC/IF	Human, Mouse, Rat, Monkey
HY-P85693	CDK5 Antibody (YA5385)	IHC-P, WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Diabetes Mellitus	Diabetes
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Psp Progressive Supranuclear Ophthalmoplegia PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Mild Cognitive Impairment
Lissencephaly 7 With Cerebellar Hypoplasia	LIS7 Lissencephaly 7, With Cerebellar Hypoplasia Lissencephaly, Type 7, With Cerebellar Hypoplasia
Scrapie
Giant Axonal Neuropathy 2
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Pick Disease Of Brain	Pick Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Pick'S Disease Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Purulent Acute Otitis Media	Acute Suppurative Otitis Media Acute Or Subacute Suppurative Otitis Media Acute Or Subacute Purulent Otitis Media
Alzheimer Disease 9	AD9 Alzheimer'S Disease 9 Alzheimer Disease 9, Susceptibility To Alzheimer Disease 9, Late-Onset Alzheimer'S Disease 9, Late Onset {Alzheimer Disease 9, Susceptibility To}
Dyslexia
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Hypothyroidism, Congenital, Nongoitrous, 6	CHNG6 Congenital Nongoitrous Hypothyroidism 6 Hypothyroidism, Congenital, Non-Goitrous, 6 Hypothyroidism, Congenital, Nongoitrous, Type 6
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Lissencephaly 1	LIS1 Classic Lissencephaly Ils Subcortical Laminar Heterotopia Lissencephaly Due To Lis1 Mutation Lissencephaly Sequence, Isolated Lissencephaly, Classic Pafah1b1-Related Lissencephaly Classical Lissencephaly Lissencephaly Type 1 Lissencephaly-1 Subcortical Band Heterotopia Double Cortex Lissencephaly Classic Lissencephaly Sequence Isolated Isolated Lissencephaly Sequence Type 1 Lissencephaly Lissencephaly Syndrome Type 1 SBH Sclh Lissencephaly, Type 1 Type I Lissencephaly
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Ischemia	Acute Coronary Syndrome
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Cerebellar Hypoplasia
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Movement Disease	Movement Disorders Movement Disorder
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Miller-Dieker Lissencephaly Syndrome	Miller-Dieker Syndrome Mds MDLS Miller Dieker Syndrome Classical Lissencephaly Syndrome Lissencephaly Due To 17p13.3 Deletion Monosomy 17p13.3 Telomeric Deletion 17p Classical Lissencephaly
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16297A	Abemaciclib	Inhibitor	99.97%	Yes
HY-10492	Dinaciclib	Inhibitor	99.80%	Yes
HY-16297	Abemaciclib methanesulfonate	Inhibitor	99.95%	Yes

Clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10580	GSK 3 Inhibitor IX	Inhibitor	99.73%	Phase 4
HY-112272A	Lerociclib dihydrochloride	Inhibitor	98.51%	Phase 3
HY-112272	Lerociclib	Inhibitor	96.42%	Phase 3
HY-30237	(R)-Roscovitine	Inhibitor	99.53%	Phase 2
HY-103712A	Samuraciclib hydrochloride	Inhibitor	99.98%	Phase 2
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-50940	AT7519	Inhibitor	99.69%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Phase 2
HY-103712	Samuraciclib	Inhibitor	99.55%	Phase 2
HY-103712B	Samuraciclib hydrochloride dihydrate	Inhibitor	99.90%	Phase 2
HY-50943	AT7519 Hydrochloride	Inhibitor	99.16%	Phase 2
HY-103712C	Samuraciclib hydrochloride hydrate	Inhibitor	99.88%	Phase 2
HY-50940A	AT7519 TFA	Inhibitor	99.75%	Phase 2
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Phase 2
HY-10012	AZD-5438	Inhibitor	99.91%	Phase 1
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-11001	PHA-793887	Inhibitor	99.25%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.75%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.67%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.09%	Phase 1

Pre-clinical Phase

Bioactive Molecules (69)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-15154	NG 52	Inhibitor	99.88%	Unkown
HY-18340	(R)-CR8	Inhibitor	99.52%	Unkown
HY-18299A	Purvalanol A	Inhibitor	98.61%	Unkown
HY-108359	Alsterpaullone	Inhibitor	99.85%	Unkown
HY-144117	GFB-12811	Inhibitor	98.04%	Unkown
HY-11009	CGP60474	Inhibitor	98.90%	Unkown
HY-13461A	PHA-767491 hydrochloride	Inhibitor	99.49%	Unkown
HY-X0150	JSH-150	Inhibitor	98.36%	Unkown
HY-103221	MeBIO	Inhibitor	98.0%	Unkown
HY-18340A	(R)-CR8 trihydrochloride	Inhibitor	99.37%	Unkown
HY-13461	PHA-767491	Inhibitor	99.97%	Unkown
HY-123772	CDK5 inhibitor 20-223	Inhibitor	99.62%	Unkown
HY-18299	Purvalanol B	Inhibitor	97.0%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-112358	GW8510	Inhibitor	99.04%	Unkown
HY-13266A	BS-181 hydrochloride	Inhibitor	99.93%	Unkown
HY-119940	MC180295	Inhibitor	98.07%	Unkown
HY-145694	CDK5-IN-3	Inhibitor	99.49%	Unkown
HY-151071	TMX-3013	Inhibitor	98.02%	Unkown
HY-W011428	Olomoucine	Inhibitor	99.88%	Unkown
HY-112403	(S)-Roscovitine	Inhibitor	99.15%	Unkown
HY-155218	TMX-2172	Degrader	99.38%	Unkown
HY-117025A	Manzamine A hydrochloride	Inhibitor	99.66%	Unkown
HY-151069	TMX-2039	Inhibitor	99.42%	Unkown
HY-121035	7BIO	Inhibitor	99.20%	Unkown
HY-107419	NU6140	Inhibitor	99.53%	Unkown
HY-137342	SB1-G-187	Degrader	98.70%	Unkown
HY-154851	GSK-3 inhibitor 3	Inhibitor	99.10%	Unkown
HY-14372	BS-194	Inhibitor	99.13%	Unkown
HY-P10440	Cdk5i peptide	Inhibitor	98.93%	Unkown
HY-139725	CDK5-IN-1	Inhibitor	98.47%	Unkown
HY-123045	PNU-292137	Inhibitor	99.95%	Unkown
HY-136726	CGP-82996	Inhibitor	98.12%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.88%	Unkown
HY-111930	5-Iodo-indirubin-3'-monoxime	Inhibitor	98.12%	Unkown
HY-119715	AG-012986	Inhibitor	99.78%	Unkown
HY-13266	BS-181	Inhibitor	98.10%	Unkown
HY-103381	NSC693868	Inhibitor	99.0%	Unkown
HY-154852	GSK-3 inhibitor 4	Inhibitor	99.02%	Unkown
HY-114903	(E/Z)-BIO-acetoxime	Inhibitor	99.9%	Unkown
HY-103383	(R)-DRF053 dihydrochloride	Inhibitor	99.30%	Unkown
HY-112468	PNU112455A hydrochloride	Inhibitor	99.56%	Unkown
HY-117025	Manzamine A	Inhibitor	98.2%	Unkown
HY-164906	TMX-2138	Degrader	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-N12625	(R)-(+)-O-Demethylbuchenavianine	Inhibitor	98.67%	Unkown
HY-151407	CDK1-IN-3	Inhibitor	/	Unkown
HY-151409	CDK1-IN-5	Inhibitor	/	Unkown
HY-110368	BS-181 dihydrochloride	Inhibitor	/	Unkown
HY-112363	Aloisine A	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-111931	Indirubin-3'-monoxime-5-sulphonic acid	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown
HY-178142	Multi-kinase-IN-7	Inhibitor	/	Unkown
HY-161595	CDK5-IN-4	Inhibitor	/	Unkown
HY-111932	Indirubin-5-sulfonate	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-150641	CDK-IN-9	Inhibitor	/	Unkown
HY-183280	17β-HSD10/CDK5-IN-1	Inhibitor	/	Unkown
HY-161463	CDK2-IN-28	Inhibitor	/	Unkown
HY-145693	CDK5-IN-2	Inhibitor	/	Unkown
HY-151408	CDK1-IN-4	Inhibitor	/	Unkown
HY-173348	BLINK15	Inhibitor	/	Unkown
HY-112336	Aloisine RP106	Inhibitor	/	Unkown
HY-182028	17β-HSD10-IN-4		/	Unkown
HY-173347	BLINK11	Inhibitor	/	Unkown
HY-182470	AG-012986 dihydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDK5	VGNC	VGNC:51795
Felis catus	CDK5	VGNC	VGNC:60700
Mus musculus	CDK5	MGD	MGI:101765
Macaca mulatta	CDK5	VGNC	VGNC:80858
Rattus norvegicus	CDK5	RGD	RGD:70514
Bos taurus	CDK5	VGNC	VGNC:27127
Others	CDK5	NCBI