Adora2b - adenosine A2b receptor Gene

Also Known as A2b; A2BR; A2BAR; AA2BR; ARA2B

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11541

About Adora2b

Chromosome 11: 62,139,810-62,157,279 forward strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 200 orthologues, 3 paralogues and is associated with 37 phenotypes. Broad expression in duodenum adult (RPKM 18.), bladder adult (RPKM 15.8) and 2 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including positive regulation of cGMP-mediated signaling; positive regulation of chronic inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is active in synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2b Products (1)

mRNA Protein Name
NM_007413.4 NP_031439.2 adenosine receptor A2b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled adenosine receptor activity IDA
IDA: Inferred from direct assay
8157966 MGI
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
16841096 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled adenosine receptor signaling pathway IDA
IDA: Inferred from direct assay
8157966 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16841096 MGI
acts upstream of cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
18340377 MGI
acts upstream of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
11454903 MGI
acts upstream of or within positive regulation of cGMP-mediated signaling IMP
IMP: Inferred from mutant phenotype
18340377 MGI
acts upstream of or within positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
18559975 MGI
acts upstream of or within positive regulation of chronic inflammatory response to non-antigenic stimulus IMP
IMP: Inferred from mutant phenotype
16841096 MGI
acts upstream of or within positive regulation of guanylate cyclase activity IMP
IMP: Inferred from mutant phenotype
18340377 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
18559975 MGI
acts upstream of or within positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
11454903 MGI
acts upstream of or within positive regulation of vascular endothelial growth factor production IMP
IMP: Inferred from mutant phenotype
18559975 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
25704806 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
25704806 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
25704806 MGI
acts upstream of or within relaxation of vascular associated smooth muscle IMP
IMP: Inferred from mutant phenotype
18340377 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
25704806 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
25704806 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
25704806 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
25704806 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25704806 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25704806 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12817016 MGI
is active in synapse IDA
IDA: Inferred from direct assay
25704806 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora2b Protein Structure

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (7 - 300)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (8 - 34)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (41 - 68)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (77 - 107)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (121 - 139)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (178 - 208)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (226 - 256)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (268 - 293)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

adenosine receptor A2b

  • A2b, Rs

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00397 ADORA2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00398 Adora2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00399 Adora2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adora2b NCBI NCBI:136