DACT3 - dishevelled binding antagonist of beta catenin 3 Gene

Also Known as RRR1; DAPPER3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 147906

About DACT3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,647,551-46,661,182 (from NCBI)

This gene has 3 transcripts (splice variants), 228 orthologues and 2 paralogues. Broad expression in brain (RPKM 11.1), endometrium (RPKM 7.4) and 17 other tissues.

Summary

Predicted to enable delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cell growth. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DACT3 Products (2)

mRNA Protein Name
NM_001301046.2 NP_001287975.1 dapper homolog 3 isoform 2
NM_145056.3 NP_659493.2 dapper homolog 3 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
18538736 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18538736 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
18538736 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DACT3 Protein Structure

Dapper

Dapper: Dapper (20 - 129)

Dapper

Dapper: Dapper (545 - 629)

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  • 629 a.a.
Protein Preferred Names Protein Names

dapper homolog 3

  • antagonist of beta-catenin Dapper homolog 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03517 DACT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DACT3 VGNC VGNC:27869
Rattus norvegicus DACT3 RGD RGD:1563892
Mus musculus DACT3 MGD MGI:3654828
Canis familiaris DACT3 VGNC VGNC:53696
Others DACT3 NCBI