INSRR - insulin receptor related receptor Gene

Also Known as IRR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3645

About INSRR

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,840,063-156,859,117 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 53 paralogues. Biased expression in kidney (RPKM 1.2), testis (RPKM 1.1) and 5 other tissues.

Summary

Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin Cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

INSRR Products (1)

mRNA Protein Name
NM_014215.3 NP_055030.1 insulin receptor-related protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
21641549 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
21641549 GOA
involved in cellular response to alkaline pH IDA
IDA: Inferred from direct assay
21641549 GOA
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
21641549 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INSRR Protein Structure

Recep_L_domain

Recep_L_domain: Receptor L domain (47 - 157)

Furin-like

Furin-like: Furin-like cysteine rich region (175 - 329)

Recep_L_domain

Recep_L_domain: Receptor L domain (346 - 454)

fn3

fn3: Fibronectin type III domain (819 - 901)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (980 - 1244)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1297 a.a.
Protein Preferred Names Protein Names

insulin receptor-related protein

  • IR-related receptor

INSRR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
INSRR P14616 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
INSRR P14616 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
INSRR P14616 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
INSRR P14616 HSP90AB1 Homo sapiens P08238
Affinity Chrom
35384245
Intra
INSRR P14616 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
Intra
INSRR P14616 HSP90AB1 Homo sapiens P08238
BioID
35384245
Intra
INSRR P14616 INSR Homo sapiens P06213
Anti Tag CoIP
33961781
Intra
INSRR P14616 INSR Homo sapiens P06213
BioID
35384245
Intra
INSRR P14616 INSR Homo sapiens P06213
Affinity Chrom
35384245
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rickettsialpox

  • Vesicular Rickettsiosis

  • Rickettsia Akari Spotted Fever

  • Doid:11103

  • Rickettsiaceae Infections

  • Kew Gardens Spotted Fever

  • Rickettsia Akari Smallpox

  • Rickettsia Akari Infection
Regular Astigmatism
Cone-Rod Dystrophy 12

  • CORD12

  • Dystrophy, Cone-Rod, Type 12
Familial Atrial Fibrillation

  • Atrial Fibrillation, Familial

  • Atfb

  • Atrial Fibrillation Autosomal Dominant

  • Autosomal Dominant Atrial Fibrillation

  • Auricular Fibrillation

  • Atrial Fibrillation

  • Atrial Fibrillation, Familial, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06849 INSRR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19448 Insrr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25940 Insrr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris INSRR VGNC VGNC:42044
Rattus norvegicus INSRR RGD RGD:67399
Bos taurus INSRR VGNC VGNC:30222
Felis catus INSRR VGNC VGNC:67812
Mus musculus INSRR MGD MGI:1346037
Macaca mulatta INSRR VGNC VGNC:106390
Others INSRR NCBI