PMAIP1 - phorbol-12-myristate-13-acetate-induced protein 1 Gene

Also Known as APR; NOXA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5366

About PMAIP1

Cytogenetic location: 18q21.32 Genomic coordinates (GRCh38): 18:59,899,996-59,904,305 (from NCBI)

This gene has 3 transcripts (splice variants) and 50 orthologues. Biased expression in bone marrow (RPKM 33.1), placenta (RPKM 8.9) and 12 other tissues.

Summary

This gene belongs to a pro-apoptotic subfamily within the Bcl-2 protein family, referred to as the Bcl-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to Apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic Bcl-2 Family members, which under steady-state conditions keep the multi-BH domain proteins Bax and Bak, in an inactive state. [provided by RefSeq, Aug 2020]

PMAIP1 Products (6)

mRNA	Protein	Name
NM_001382615.1	NP_001369544.1	phorbol-12-myristate-13-acetate-induced protein 1 isoform 5
NM_001382616.1	NP_001369545.1	phorbol-12-myristate-13-acetate-induced protein 1 isoform 1
NM_001382617.1	NP_001369546.1	phorbol-12-myristate-13-acetate-induced protein 1 isoform 3
NM_001382618.1	NP_001369547.1	phorbol-12-myristate-13-acetate-induced protein 1 isoform 2
NM_001382623.1	NP_001369552.1	phorbol-12-myristate-13-acetate-induced protein 1 isoform 4
NM_021127.3	NP_066950.1	phorbol-12-myristate-13-acetate-induced protein 1 isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15705586	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	17599062	GOA
involved in cellular response to glucose starvation	IMP IMP: Inferred from mutant phenotype	21145489	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	14699081	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	15705586	GOA
involved in intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14500711	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15102863	GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15102863	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21132008	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17289999	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	14699081	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	15705586	GOA
involved in positive regulation of glucose metabolic process	IDA IDA: Inferred from direct assay	21145489	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21454712	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	14500711	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	15705586	GOA
involved in proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	15901672	GOA
involved in reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	14699081	GOA
involved in regulation of mitochondrial membrane permeability	IDA IDA: Inferred from direct assay	14500711	GOA
involved in response to dsRNA	IDA IDA: Inferred from direct assay	15705586	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Bcl-2 family protein complex	IPI IPI: Inferred from physical interaction	21132008	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15705586	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	14500711	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12879012	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PMAIP1 Protein Structure

PMAIP1

0
54 a.a.

Protein Preferred Names	Protein Names
phorbol-12-myristate-13-acetate-induced protein 1	PMA-induced protein 1

PMAIP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PMAIP1	Q13794	BCL2	Homo sapiens	P10415-1	Pull Down	21454712
Intra	PMAIP1	Q13794	BCL2	Homo sapiens	P10415	Pull Down	21454712
Intra	PMAIP1	Q13794	BCL2	Homo sapiens	P10415	Anti Bait CoIP	21454712

Cross: Cross-species interaction Intra: Intraspecies interaction

PMAIP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82808	NOXA Antibody (YA2553)	WB	Human
HY-P82808A	NOXA Antibody (YA2553)(PBS only)	WB	Human

Related Diseases

Diseases	Alias
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Rhabdomyosarcoma
Pyriform Sinus Cancer	Malignant Neoplasm Of Pyriform Fossa Malignant Neoplasm Of The Pyriform Fossa Malignant Tumor Of Pyriform Fossa
Hyperinsulinemic Hypoglycemia, Familial, 1	HHF1 Persistent Hyperinsulinemic Hypoglycemia Of Infancy Familial Hyperinsulinemic Hypoglycemia 1 Congenital Hyperinsulinism Phhi Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Of Infancy Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia Nesidioblastosis Of Pancreas Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis Hyperinsulinism, Congenital Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency Hypoglycemia, Hyperinsulinemic, Familial, Type 1
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10758	PMAIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20580	Pmaip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27088	Pmaip1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PMAIP1	VGNC	VGNC:53752
Bos taurus	PMAIP1	VGNC	VGNC:106870
Mus musculus	PMAIP1	MGD	MGI:1930146
Rattus norvegicus	PMAIP1	RGD	RGD:1359266
Felis catus	PMAIP1	VGNC	VGNC:107717
Others	PMAIP1	NCBI