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ARAP3 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Gene

Also Known as DRAG1; CENTD3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64411

About ARAP3

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,653,402-141,682,230 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 28 paralogues. Broad expression in lung (RPKM 9.2), fat (RPKM 7.9) and 24 other tissues.

Summary

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell Cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2015]

ARAP3 Products (1)

mRNA	Protein	Name
NM_022481.6	NP_071926.4	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	11804589	GOA
enables phosphatidylinositol-3,4-bisphosphate binding	IDA IDA: Inferred from direct assay	11804589	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15090612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARAP3 Protein Structure

SAM_2

ArfGap

RhoGAP

0
300
600
900
1200
1544 a.a.

Protein Preferred Names	Protein Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3

ARAP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARAP3	Q8WWN8	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	15090612

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Oropharyngeal Anthrax
Hyaline Fibromatosis Syndrome	Juvenile Hyaline Fibromatosis Inherited Systemic Hyalinosis Puretic Syndrome Infantile Systemic Hyalinosis HFS Hyalinosis, Systemic Systemic Hyalinosis Molluscum Fibrosum Murray Syndrome Murray-Puretic-Drescher Syndrome Ish Jhf Fibromatosis, Juvenile Hyaline Hyalinosis, Systemic Infantile Fibromatosis, Hyaline Syndrome Neurofibromatosis 1
Gastrointestinal Anthrax

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00889	ARAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21483	Arap3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28001	Arap3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARAP3	MGD	MGI:2147274
Macaca mulatta	ARAP3	VGNC	VGNC:69893
Canis familiaris	ARAP3	VGNC	VGNC:38027
Rattus norvegicus	ARAP3	RGD	RGD:1304938
Felis catus	ARAP3	VGNC	VGNC:59864
Bos taurus	ARAP3	VGNC	VGNC:58361
Others	ARAP3	NCBI