ELL3 - elongation factor for RNA polymerase II 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80237

About ELL3

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,772,620-43,776,966 (from NCBI)

This gene has 8 transcripts (splice variants), 356 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 75.8), prostate (RPKM 58.8) and 25 other tissues.

Summary

Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription, DNA-templated and transcription by RNA polymerase II. Located in several cellular components, including chromosome; cytosol; and nuclear lumen. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ELL3 Products (1)

mRNA Protein Name
NM_025165.3 NP_079441.1 RNA polymerase II elongation factor ELL3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21729782 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription elongation IDA
IDA: Inferred from direct assay
10882741 GOA
involved in positive regulation of DNA-templated transcription, elongation IDA
IDA: Inferred from direct assay
10882741 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10882741 GOA
involved in snRNA transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22195968 GOA
involved in transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
10882741 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
10882741 GOA
part of transcription elongation factor complex IDA
IDA: Inferred from direct assay
22195968 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELL3 Protein Structure

ELL

ELL: RNA polymerase II elongation factor ELL (6 - 239)

Occludin_ELL

Occludin_ELL: Occludin homology domain (291 - 391)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

RNA polymerase II elongation factor ELL3

  • elongation factor RNA polymerase II-like 3

ELL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ELL3 Q9HB65 EAF1 Homo sapiens Q96JC9
Y2H Prey Pooling
32296183
Intra
ELL3 Q9HB65 EAF1 Homo sapiens Q96JC9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cns Neuroblastoma With Foxr2 Activation

  • Central Nervous System Neuroblastoma With Foxr2 Activation

  • Cns Nb-Foxr2

  • Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor

  • Central Nervous System Germ Cell Tumour

  • Germ Cell Tumor Of The Cns

  • Germ Cell Tumour Of The Cns
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04310 ELL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ELL3 MGD MGI:2673679
Macaca mulatta ELL3 VGNC VGNC:72087
Canis familiaris ELL3 VGNC VGNC:40308
Felis catus ELL3 VGNC VGNC:61814
Bos taurus ELL3 VGNC VGNC:28437
Rattus norvegicus ELL3 RGD RGD:1309917
Others ELL3 NCBI