NETO1 - neuropilin and tolloid like 1 Gene

Also Known as BCTL1; BTCL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81832

About NETO1

Cytogenetic location: 18q22.3 Genomic coordinates (GRCh38): 18:72,742,314-72,867,987 (from NCBI)

This gene has 7 transcripts (splice variants), 268 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.4) and spleen (RPKM 0.5).

Summary

This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]

NETO1 Products (8)

mRNA Protein Name
NM_001201465.3 NP_001188394.2 neuropilin and tolloid-like protein 1 isoform 3 precursor
NM_001354017.2 NP_001340946.2 neuropilin and tolloid-like protein 1 isoform 3 precursor
NM_001354018.2 NP_001340947.2 neuropilin and tolloid-like protein 1 isoform 4
NM_001354020.2 NP_001340949.2 neuropilin and tolloid-like protein 1 isoform 5
NM_001354021.2 NP_001340950.1 neuropilin and tolloid-like protein 1 isoform 6 precursor
NM_001354022.2 NP_001340951.1 neuropilin and tolloid-like protein 1 isoform 7
NM_138966.5 NP_620416.2 neuropilin and tolloid-like protein 1 isoform 3 precursor
NM_138999.2 NP_620552.1 neuropilin and tolloid-like protein 1 isoform 1 precursor

NETO1 Protein Structure

CUB

CUB: CUB domain (41 - 152)

CUB

CUB: CUB domain (193 - 283)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (291 - 326)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
Protein Preferred Names Protein Names

neuropilin and tolloid-like protein 1

  • brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1

Recombinant NETO1 Proteins

Cat. No. Product Name Accession Purity
HY-P75937 NETO1 Protein, Human (HEK293, His) Q8TDF5-3 (T23-T344) ≥ 95%, as determined by reducing SDS-PAGE.

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Orthologs Information

Species Symbol Source ID
Canis familiaris NETO1 VGNC VGNC:43748
Bos taurus NETO1 VGNC VGNC:32011
Felis catus NETO1 VGNC VGNC:63780
Macaca mulatta NETO1 VGNC VGNC:75172
Mus musculus NETO1 MGD MGI:2180216
Rattus norvegicus NETO1 RGD RGD:1566269
Others NETO1 NCBI