NETO1 - neuropilin and tolloid like 1 Gene
Also Known as BCTL1; BTCL1
Species: Homo sapiens
About NETO1
This gene has 7 transcripts (splice variants), 268 orthologues and 35 paralogues. Biased expression in brain (RPKM 5.4) and spleen (RPKM 0.5).
Summary
This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]
NETO1 Products (8)
| mRNA | Protein | Name |
|---|---|---|
| NM_001201465.3 | NP_001188394.2 | neuropilin and tolloid-like protein 1 isoform 3 precursor |
| NM_001354017.2 | NP_001340946.2 | neuropilin and tolloid-like protein 1 isoform 3 precursor |
| NM_001354018.2 | NP_001340947.2 | neuropilin and tolloid-like protein 1 isoform 4 |
| NM_001354020.2 | NP_001340949.2 | neuropilin and tolloid-like protein 1 isoform 5 |
| NM_001354021.2 | NP_001340950.1 | neuropilin and tolloid-like protein 1 isoform 6 precursor |
| NM_001354022.2 | NP_001340951.1 | neuropilin and tolloid-like protein 1 isoform 7 |
| NM_138966.5 | NP_620416.2 | neuropilin and tolloid-like protein 1 isoform 3 precursor |
| NM_138999.2 | NP_620552.1 | neuropilin and tolloid-like protein 1 isoform 1 precursor |
NETO1 Protein Structure
CUB: CUB domain (41 - 152)
CUB: CUB domain (193 - 283)
Ldl_recept_a: Low-density lipoprotein receptor domain class A (291 - 326)
- 0
- 100
- 200
- 300
- 400
- 500
- 533 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
neuropilin and tolloid-like protein 1 |
|
Recombinant NETO1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P75937 | NETO1 Protein, Human (HEK293, His) | Q8TDF5-3 (T23-T344) | ≥ 95%, as determined by reducing SDS-PAGE. |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | NETO1 | VGNC | VGNC:43748 |
| Bos taurus | NETO1 | VGNC | VGNC:32011 |
| Felis catus | NETO1 | VGNC | VGNC:63780 |
| Macaca mulatta | NETO1 | VGNC | VGNC:75172 |
| Mus musculus | NETO1 | MGD | MGI:2180216 |
| Rattus norvegicus | NETO1 | RGD | RGD:1566269 |
| Others | NETO1 | NCBI |