PAK1-IN-3
PAK1-IN-3 is a PAK1 inhibitor with an IC50 of 10 nM, an IC50 of 20 nM against PAK2, and an IC50 of 1079 nM against hERG potassium channels. PAK1-IN-3 forms a salt bridge with Asp106 in PAK1 via a properly positioned tertiary amine. PAK1-IN-3 inhibits PAK2 and hERG potassium channels.
For research use only. We do not sell to patients.
- Formula: C27H31ClN8O2
- Molecular Weight:535.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PAK1 10 nM (IC50) |
PAK2 20 nM (IC50) |
PAK1-IN-3 (Compound 12) has a logD7.4 of 3.02, moderate solubility in PBS pH 7.4, high plasma protein binding, parent-like metabolic stability in human hepatocytes, and efflux ratios of 0.7 in MDCKII cells and 2.9 in Caco-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 535.04
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Formula C27H31ClN8O2
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SMILES
O=C1C(C2=CC=C(C3=NC(C)=CN=C3)C=C2Cl)=CC4=CN=C(NCCN5OCCN(C)CC5)N=C4N1CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAK1-IN-3 Related Classifications
HY-182357 Related Classifications
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