Pep19-2.5
Based on 1 publication(s) in Google Scholar
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis.
For research use only. We do not sell to patients.
- Purity: 98.98%
- CAS No.: 1322711-38-5
- Formula: C135H187N37O22S
- Molecular Weight:2712.23
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pep19-2.5
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sepsis model in male New Zealand rabbits (2-2.5 kg)[2]
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Dosage:5 mg/kg, combinded with 15 mg/kg Ceftriaxone; total volume of 2 mL
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Administration:Intravenous injection; extracted blood from the marginal ear vein at different time points post challenge (0, 2, 30, 90 and 180 min)
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Result:Killed bacteria and eliminates bacteremia 30 min post challenge;
Inhibited Toll-like receptor 4 agonists in serum 90 min post challenge;
Reduced serum levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor α);
And reverted to hypothermia and gives rise to temperature values indistinguishable from basal levels 330 min post challenge.
Chemical Information
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CAS No. 1322711-38-5
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Appearance Solid
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Molecular Weight 2712.23
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Formula C135H187N37O22S
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Color White to off-white
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Sequence Shortening
GCKKYRRFRWKFKGKFWFWG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Behav Brain Res
Serotonin mitigates depression in a rotenone-induced mouse Parkinson's disease model by inhibiting hippocampal neuronal pyroptosis and neuroinflammation. [Abstract]2025 May 7:115620. PMID: 40345554
Purity & Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Heinbockel L, et al. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5. Front Immunol. 2018 Jul 26;9:1704. [Content Brief]
[2]. Bárcena-Varela S, et al. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Exp Mol Med. 2017 Jun 16;49(6):e345. [Content Brief]
[3]. Jannadi H, et al. Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation. Microb Pathog. 2019 Aug;133:103546. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pep19-2.5 Related Classifications
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