Translocation t(3;22)(q23;q11) in three patients with diffuse large B cell lymphoma

  • Leukemia. 1990 May;4(5):373-6.
D Leroux  1 ,  M Stul ,  J J Sotto ,  C Bastard ,  P Couderc ,  J C Bensa ,  M Monteil ,  J J Cassiman ,  P Jalbert
Affiliations
  • 1. Department of Genetics, University Hospital, Grenoble, France.
PMID: 2201829
Abstract

In our series of 134 patients with a diagnosis of non-Hodgkin's lymphoma (NHL) and clonal chromosomal abnormalities, three were found to show an identical t(3;22)(q28;q11) translocation. All were old patients with isolated lymphadenomegaly and diffuse large noncleaved cell lymphoma. All expressed a B cell immunophenotype, and all entered a complete remission when treated with aggressive chemotherapy. This translocation could, therefore, delineate a particular subtype of diffuse large cell NHL.

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