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Cat. No.: HY-154387

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1-Isopropyltryptophan

Name: 1-Isopropyltryptophan
Brand: MedChemExpress
SKU: HY-154387
Availability: PreOrder

(Synonyms: 1-IsoPT)

1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA.

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CAS No.: 1219485-46-7
Formule: C₁₄H₁₈N₂O₂
Masse moléculaire:246.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

1-Isopropyltryptophan Chemical Structure

CAS No.: 1219485-46-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

1-Isopropyltryptophan (1-IsoPT) is a IDO1 inhibitor. 1-Isopropyltryptophan decreases the expression of IFN-γ stimulated ID0-1 and ID0-2 mRNA^[1].

IC₅₀ & Target

^[1]

IDO1

Voir tous les produits spécifiques à Isoform Indoleamine 2,3-Dioxygenase (IDO) :

In Vitro

1-Isopropyltryptophan (24 h) shows cytotoxicity for mouse DC 2.4 lines with an IC₅₀ value of 2.156 mM^[1].
1-Isopropyltryptophan (100 µM; 48 h) decreases the expression of IFN-γ (0.5 µg/ml) stimulated IDO-1 and IDO-2 mRNA in DC 2.4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

DC 2.4 cells
Concentration:

100 µM
Incubation Time:

48 h
Result:

Decreased the ID0-1 and ID0-2 mRNA expression in IFN-γ (0.5 lg/ml) treated DCs.

Chemical Information

CAS No. 1219485-46-7
Masse moléculaire 246.30
Formule C₁₄H₁₈N₂O₂
SMILES

N[C@@H](CC1=CN(C(C)C)C2=C1C=CC=C2)C(O)=O
Synonyms

1-IsoPT
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sun T, et al. Novel 1-alkyl-tryptophan derivatives downregulate IDO1 and IDO2 mRNA expression induced by interferon-gamma in dendritic cells. Mol Cell Biochem. 2010 Sep;342(1-2):29-34. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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