LH846
Based on 2 publication(s) in Google Scholar
LH846 is a selective inhibitor of CKIδ, with an IC50 of 290 nM, and less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively.
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- Pureté: 98.89%
- CAS No.: 639052-78-1
- Formule: C16H13ClN2OS
- Masse moléculaire:316.81
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LH846
More
Activité biologique
Description
IC50 & Target
[1]|
CK1δ 290 nM (IC50) |
CK1α/CSNK1A1 2.5 μM (IC50) |
In Vitro
LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 639052-78-1
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Appearance Solid
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Masse moléculaire 316.81
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Formule C16H13ClN2OS
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Color Off-white to pale purple
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SMILES
O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Cancer
Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity. [Abstract]2025 May;6(5):768-785. PMID: 40108413 -
Solvant et solubilité
In Vitro:
DMSO : ≥ 33.33 mg/mL (105.21 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1565 mL | 15.7823 mL | 31.5647 mL | 78.9117 mL |
| 5 mM | 0.6313 mL | 3.1565 mL | 6.3129 mL | 15.7823 mL | |
| 10 mM | 0.3156 mL | 1.5782 mL | 3.1565 mL | 7.8912 mL | |
| 15 mM | 0.2104 mL | 1.0522 mL | 2.1043 mL | 5.2608 mL | |
| 20 mM | 0.1578 mL | 0.7891 mL | 1.5782 mL | 3.9456 mL | |
| 25 mM | 0.1263 mL | 0.6313 mL | 1.2626 mL | 3.1565 mL | |
| 30 mM | 0.1052 mL | 0.5261 mL | 1.0522 mL | 2.6304 mL | |
| 40 mM | 0.0789 mL | 0.3946 mL | 0.7891 mL | 1.9728 mL | |
| 50 mM | 0.0631 mL | 0.3156 mL | 0.6313 mL | 1.5782 mL | |
| 60 mM | 0.0526 mL | 0.2630 mL | 0.5261 mL | 1.3152 mL | |
| 80 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9864 mL | |
| 100 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.7891 mL |
LH846 Related Classifications
HY-15704 Related Classifications
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