GSK1940029
Based on 3 publication(s) in Google Scholar
GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor extracted from patent WO/2009060053 A1, compound example 16.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.82%
- CAS No.: 1150701-66-8
- Formule: C18H16Cl2N4O2
- Masse moléculaire:391.25
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) GSK1940029
More
Activité biologique
Stearoyl-CoA Desaturase (SCD)[1]
GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD), which can be used to treat and/or preventing various diseases, including those mediated by SCD enzyme, such as diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, skin disorders such as acne, diseases or conditions related to cancer and the treatment of symptoms linked to the production of the amyloid plaque-forming Aβ42 peptide such as Alzheimer's disease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1150701-66-8
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Appearance Solid
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Masse moléculaire 391.25
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Formule C18H16Cl2N4O2
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Color Light yellow to yellow
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SMILES
ClC(C=CC(CN1N=NC(C(NC2=CC=C(CO)C=C2)=O)=C1C)=C3)=C3Cl
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Synonyms
SCD inhibitor 1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Mol Cell
Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. [Abstract]2019 Mar 7;73(5):1001-1014.e8. PMID: 30527540 -
Int J Mol Sci
Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor. [Abstract]2020 Jul 22;21(15):5193. PMID: 32707907 -
Am J Physiol Cell Physiol
Increasing cellular NAD+ protects hepatocytes against palmitate-induced lipotoxicity by preventing PARP-1 inhibition and the mTORC1-p300 pathway activation. [Abstract]2025 Mar 1;328(3):C776-C790. PMID: 39871470
Solvant et solubilité
DMSO : ≥ 32 mg/mL (81.79 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.5559 mL | 12.7796 mL | 25.5591 mL | 63.8978 mL |
| 5 mM | 0.5112 mL | 2.5559 mL | 5.1118 mL | 12.7796 mL | |
| 10 mM | 0.2556 mL | 1.2780 mL | 2.5559 mL | 6.3898 mL | |
| 15 mM | 0.1704 mL | 0.8520 mL | 1.7039 mL | 4.2599 mL | |
| 20 mM | 0.1278 mL | 0.6390 mL | 1.2780 mL | 3.1949 mL | |
| 25 mM | 0.1022 mL | 0.5112 mL | 1.0224 mL | 2.5559 mL | |
| 30 mM | 0.0852 mL | 0.4260 mL | 0.8520 mL | 2.1299 mL | |
| 40 mM | 0.0639 mL | 0.3195 mL | 0.6390 mL | 1.5974 mL | |
| 50 mM | 0.0511 mL | 0.2556 mL | 0.5112 mL | 1.2780 mL | |
| 60 mM | 0.0426 mL | 0.2130 mL | 0.4260 mL | 1.0650 mL | |
| 80 mM | 0.0319 mL | 0.1597 mL | 0.3195 mL | 0.7987 mL |
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