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Cat. No.: HY-153399A

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Fosigotifator THAM sodium

(Synonyms: ABBV-CLS-7262 THAM sodium)

Fosigotifator (ABBV-CLS-7262) THAM sodium is a brain penetrant, orally active EIF2b (eukaryotic initiation factor) activator. Fosigotifator THAM sodium stabilizes the elF2B complex and boosts the activity, including that of complexes carrying pathogenic vanishing white matter (VWM) mutations. Fosigotifator THAM sodium is an integrated stress response inhibitor (ISRI). Fosigotifator THAM sodium can be used for amyotrophic lateral sclerosis research.

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CAS No.: 2945073-88-9
Formule: C₂₉H₃₇Cl₂F₂N₃NaO₁₂P
Masse moléculaire:782.48

Stockage:

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Fosigotifator THAM sodium Chemical Structure

CAS No.: 2945073-88-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vivo

Fosigotifator THAM sodium improves motor dysfunction in a VWM mouse model. Simultaneously, integrated stress response (ISR) gene expression and pharmacodynamic biomarkers also underwent corresponding changes. Furthermore, neurofilament light chain (NfL) levels are significantly reduced in VWM mice treated with Fosigotifator THAM sodium^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 2945073-88-9
Appearance Solid
Masse moléculaire 782.48
Formule C₂₉H₃₇Cl₂F₂N₃NaO₁₂P
Color White to off-white
SMILES

O=C(COC(C=C1)=CC(F)=C1Cl)NC(CCC23NC(COC(C=C4)=CC(F)=C4Cl)=O)(CC2)[C@H](C3)OCO[P](O)(O[Na])=O.OCC(CO)(N)CO
Synonyms

ABBV-CLS-7262 THAM sodium
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Michael Hayden, et al. Method of treating amyotrophic lateral sclerosis with pridopidine. US20230190724 A1. 2023.6.22.

[2]. Amos Baruch, et al. Development of eIF2B Activator ABBV-CLS-7262 as a Novel Treatment for Vanishing White Matter Disease (P2-8.001). Neurology. Volume 102 Number 7 April 09,2024

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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