BCL6-IN-6
Based on 1 Customer Validation
BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.10%
- CAS No.: 2408882-54-0
- Formule: C27H31FN6O2S
- Masse moléculaire:522.64
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
BCL6[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DOHH-2 | IC50 |
1 μM
Compound: 28
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Antiproliferative activity against BCL-6 dependent human DOHH-2 cells by CCK-8 assay
Antiproliferative activity against BCL-6 dependent human DOHH-2 cells by CCK-8 assay
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[PMID: 33844535] |
| DOHH-2 | IC50 |
1.21 μM
Compound: 14j
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Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| Farage | IC50 |
1 μM
Compound: 28
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Antiproliferative activity against BCL-6 dependent human Farage cells by CCK-8 assay
Antiproliferative activity against BCL-6 dependent human Farage cells by CCK-8 assay
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[PMID: 33844535] |
| Farage | IC50 |
1.26 μM
Compound: 14j
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Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| L02 | IC50 |
13.1 μM
Compound: 14j
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Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| NCM460 | IC50 |
32.4 μM
Compound: 14j
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Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| OCI-Ly7 | IC50 |
1 μM
Compound: 28
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Antiproliferative activity against BCL-6 dependent human OCILY7 cells by CCK-8 assay
Antiproliferative activity against BCL-6 dependent human OCILY7 cells by CCK-8 assay
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[PMID: 33844535] |
| OCI-Ly7 | IC50 |
1.62 μM
Compound: 14j
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Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| PNT1A | IC50 |
8.13 μM
Compound: 14j
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Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| SUD4 | IC50 |
0.92 μM
Compound: 14j
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Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| SUD4 | IC50 |
1 μM
Compound: 28
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Antiproliferative activity against BCL-6 dependent human SU-DHL-4 cells by CCK-8 assay
Antiproliferative activity against BCL-6 dependent human SU-DHL-4 cells by CCK-8 assay
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[PMID: 33844535] |
| Toledo | IC50 |
3.25 μM
Compound: 14j
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Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| Toledo | IC50 |
3.3 μM
Compound: 28
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Antiproliferative activity against BCL-6 independent human Toledo cells by CCK-8 assay
Antiproliferative activity against BCL-6 independent human Toledo cells by CCK-8 assay
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[PMID: 33844535] |
Chemical Information
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CAS No. 2408882-54-0
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Appearance Solid
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Masse moléculaire 522.64
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Formule C27H31FN6O2S
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=C(C2=CCCC2)S1)NC3=CC=C(NC4=NC(N5C[C@@H](C)N[C@@H](C)C5)=NC=C4F)C=C3OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : ≥ 4 mg/mL (7.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9134 mL | 9.5668 mL | 19.1336 mL | 47.8341 mL |
| 5 mM | 0.3827 mL | 1.9134 mL | 3.8267 mL | 9.5668 mL |
BCL6-IN-6 Related Classifications
HY-143653 Related Classifications
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