BMS-536924 (Standard)
BMS-536924 (Standard) is the analytical standard of BMS-536924 (HY-10262). This product is intended for research and analytical applications. BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity.
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- CAS No.: 468740-43-4
- Formule: C25H26ClN5O3
- Masse moléculaire:479.96
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureté et documentation
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Help & FAQs
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HY-10262
BMS-536924IGF-1R/IR Inhibitor -
HY-10191
LinsitinibIGF-1R/Insulin Receptor Inhibitor -
HY-10200
BMS-754807IGF-1R/IR Inhibitor -
HY-50866
NVP-AEW541IGF-1R/IR Inhibitor -
HY-10253
AG1024IGF-1R Inhibitor -
HY-15494
PicropodophyllinApoptosis Inducer -
HY-10524
GSK1904529AIGF-1R Inhibitor -
HY-13686
PQ401IGF-1R Inhibitor -
HY-10252
NVP-ADW742IGF-1R Inhibitor -
HY-P0035
Insulin (human)Recombinant Human Insulin -
HY-P0035A
Insulin solution (human)Polypeptide Hormone -
HY-N0908
Ginsenoside Rg5IGF-1R Agonist
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 468740-43-4
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Masse moléculaire 479.96
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Formule C25H26ClN5O3
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SMILES
O=C1C(C2=NC3=CC(N4CCOCC4)=CC(C)=C3N2)=C(C=CN1)NC[C@@H](O)C5=CC=CC(Cl)=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Wittman M, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem. 2005 Sep 8;48(18):5639-43. [Content Brief]
[2]. Litzenburger BC, et al. BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res. 2009 Jan 1;15(1):226-37. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-536924 (Standard) Related Classifications
HY-10262R Related Classifications
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