Bursehernin
Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin induces Apoptosis and cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity.
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- CAS No.: 40456-51-7
- Formule: C21H22O6
- Masse moléculaire:370.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Bursehernin (4.3 µM for MCF-7 cells, 3.7 µM for KKU-M213 cells; 4, 48, 72 h) induces apoptosis and cell cycle arrest at G2/M phase in a time-dependent manner [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MDA-MB-468, MDA-MB-231, HT-29, KKU-M213, KKU-K100, KKU-M055, L-929, MMNK-1 cells
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Concentration:0-100 µM
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Incubation Time:72 h
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Result:Showed anti-proliferative activity with IC50s of 11.96, 8.24, 14.26, 47.53, 3.70, 12.38, 17.38, 26.36, 7.45 µM for MCF-7, MDA-MB-468, MDA-MB-231, HT-29, KKU-M213, KKU-K100, KKU-M055, L-929, MMNK-1 cells, respectively.
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Cell Line:MCF-7, KKU-M213 cells
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Concentration:4.3 µM for MCF-7 cells, 3.7 µM for KKU-M213 cells
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Incubation Time:24, 48, 72 h
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Result:Induced cell cycle arrest at G2/M phase.
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Cell Line:MCF-7, KKU-M213 cells
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Concentration:4.3 µM for MCF-7 cells, 3.7 µM for KKU-M213 cells
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Incubation Time:24, 48, 72 h
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Result:Decreased the expression of topoisomerase II, STAT 3, cyclin D1, and p21.
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Cell Line:MCF-7 cells
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Concentration:0, 2.15, 4.30, 8.60 µM
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Incubation Time:24, 48, 72, 96 h
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Result:Induced apoptosis in a time- and dose-dependent manner.
Chemical Information
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CAS No. 40456-51-7
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Masse moléculaire 370.40
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Formule C21H22O6
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SMILES
O=C1OC[C@H](CC2=CC=C(OCO3)C3=C2)[C@H]1CC4=CC(OC)=C(C=C4)OC
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Synonyms
Methylpluviatolide
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Rattanaburee T, et al. Anticancer activity of synthetic (±)-kusunokinin and its derivative (±)-bursehernin on human cancer cell lines. Biomed Pharmacother. 2019 Sep;117:109115. [Content Brief]
[2]. McDoniel PB, et al. Antitumor activity of Bursera schlechtendalii (burseraceae): isolation and structure determination of two new lignans. J Pharm Sci. 1972 Dec;61(12):1992-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bursehernin Related Classifications
HY-N10670 Related Classifications
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