CB 3705
CB 3705 is a dihydrofolate reductase (DHFR) and thymidylate synthetase (TS) inhibitor. CB 3705 inhibits L1210 cells and mutant L1210 cell line (L1210:C15) with ID50s of 4.77 μM and 408 μM, respectively.
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- CAS No.: 5854-11-5
- Formule: C21H21N5O6
- Masse moléculaire:439.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
2.7 μM
Compound: 5,8-deazafolate
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Ability to inhibit thymidylate synthase derived from human leukemia K562 cells
Ability to inhibit thymidylate synthase derived from human leukemia K562 cells
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[PMID: 3470522] |
| L1210 | IC50 |
0.1 mM
Compound: table II
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Evaluated for the inhibition of thymidylate synthase in intact L1210 cells
Evaluated for the inhibition of thymidylate synthase in intact L1210 cells
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[PMID: 3599032] |
| L1210 | IC50 |
1.00E-05 M
Compound: table II
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Evaluated for the inhibition of thymidylate synthase in permeabilised L1210 cells
Evaluated for the inhibition of thymidylate synthase in permeabilised L1210 cells
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[PMID: 3599032] |
Chemical Information
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CAS No. 5854-11-5
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Masse moléculaire 439.42
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Formule C21H21N5O6
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SMILES
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CC3=C(NC(N)=NC3=O)C=C2)C=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Calvert AH, et al. Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance. Eur J Cancer (1965). 1980 May;16(5):713-22. [Content Brief]
[2]. Jackman AL, et al. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies. Cancer Res. 1986 Jun;46(6):2810-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB 3705 Related Classifications
HY-122045 Related Classifications
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