CBR Agonist-1
CBR Agonist-1 (27a-cis) is a cannabinoid receptor (CBR) agonist with the Ki values of 0.18 μM for CB1R and 1.22 μM for CB2R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases.
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- Formule: C27H27FN4O
- Masse moléculaire:442.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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rCB1-R 0.18 μM (Ki) |
hCB2-R 1.22 μM (Ki) |
CBR Agonist-1 (27a-cis) (24 h) can activate GRABeCB2.0 (fluorescent CB1R sensor) in a concentration-dependent manner with the EC50 value of 2.1 μM in HEK293T cell lines[1].
CBR Agonist-1 (27a-cis) (0-10 mM) acts on hCB1R calcium mobilization with the IC50 value of 3.10 μM in overexpressed hCB1R CHO-K1cells[1].
CBR Agonist-1 (27a-cis) (10-1000 nM, 15 min) induces increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in a dose-dependent manner in expressed Gαq16 and hCB1 CHO cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 442.53
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Formule C27H27FN4O
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SMILES
O=C(C1=CN(C2=CC=CC=C12)CCCCCF)NCC3=CC=CC=C3/N=N\C4=CC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBR Agonist-1 Related Classifications
HY-151105 Related Classifications
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