CGS-9896
CGS-9896 is an orally active benzodiazepine receptor agonist that targets the benzodiazepine receptor allosterically coupled to the GABAA receptor and chloride ion carrier channel. The Ki value of CGS-9896 for benzodiazepine receptors in rats is 0.83 nM. CGS-9896 inhibits pentylenetetrazol-induced convulsions in mice and exerts an anticonvulsant effect.
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- CAS No.: 77779-36-3
- Formule: C16H10ClN3O
- Masse moléculaire:295.73
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male mice[1]
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Dosage:1.17 mg/kg
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Administration:p.o.
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Result:Exhibited agonist (anticonvulsant) activity with an ED50 of 1.17 mg/kg, representing the dose required to prevent tonic convulsions and death in 50% of treated mice.
Chemical Information
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CAS No. 77779-36-3
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Appearance Solid
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Masse moléculaire 295.73
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Formule C16H10ClN3O
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Color Light yellow to yellow
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SMILES
O=C1C2=CNC=3C=CC=CC3C2=NN1C4=CC=C(Cl)C=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CGS-9896 Related Classifications
HY-103052 Related Classifications
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