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Cat. No.: HY-184440

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Complex I-IN-1

Complex I-IN-1 is a novel fungicide that acts as a mitochondrial complex I inhibitor. Complex I-IN-1 regulates oxidoreductase activity, glycolysis/gluconeogenesis, methionine metabolism, and the MAPK signaling pathway in Blumeria graminis. Complex I-IN-1 is applicable to research related to wheat powdery mildew.

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CAS No.: 3080323-62-9
Formule: C₁₆H₁₂Cl₅F₂N₃O₂
Masse moléculaire:493.55

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Complex I-IN-1 Chemical Structure

CAS No.: 3080323-62-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

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In Vitro

Complex I-IN-1 (compound 3) binds to the active site of yeast mitochondrial Complex I and interacts with surrounding key amino acid residues, which is consistent with its function as a Complex I inhibitor^[1].
Complex I-IN-1 exhibits excellent activity against wheat powdery mildew (EC₅₀ = 0.440 mg/L)^[1].
Complex I-IN-1 alters gene expression in mycelia of Blumeria graminis, and the differentially expressed genes (DEGs) are enriched in pathways associated with mitochondrial complex I function, confirming complex I as its potential target^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3080323-62-9
Masse moléculaire 493.55
Formule C₁₆H₁₂Cl₅F₂N₃O₂
SMILES

Cl/C(Cl)=C/COC1=CC(Cl)=C(OCCNC2=C(Cl)C(C(F)F)=NC=N2)C(Cl)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Jia WF, et al. Design, Synthesis, and Fungicidal Activity of Pyrimidinamine Derivatives as Novel Complex I Inhibitors. Journal of agricultural and food chemistry. 2026 Jun 24;74(24):18551-18563. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Complex I-IN-1

Voir tous les produits spécifiques à Isoform p38 MAPK