DTLMISR
DTLMISR is a tryptic peptide widely present in the Fc regions of all four human IgG subclasses. DTLMISR contains a methionine residue susceptible to both post-translational modification oxidation and artificial oxidation, and its oxidized form requires specific detection via LC-MRM before SILuMAb aliquoting and storage.
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- CAS No.: 762266-54-6
- Formule: C34H62N10O12S
- Masse moléculaire:834.98
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 762266-54-6
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Masse moléculaire 834.98
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Formule C34H62N10O12S
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SMILES
O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CO)=O)[C@H](CC)C)=O)CCSC)=O)CC(C)C)=O)[C@@H](C)O
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Sequence
Asp-Thr-Leu-Met-Ile-Ser-Arg
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Sequence Shortening
DTLMISR
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lesur A, Varesio E, Hopfgartner G. Protein quantification by MALDI-selected reaction monitoring mass spectrometry using sulfonate derivatized peptides. Analytical chemistry. 2010 Jun 15;82(12):5227-37. [Content Brief]
[2]. Vialaret J, Broutin S, Pugnier C, et al.. What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?. Bioanalysis. 2018 May 01;10(10):723-735. [Content Brief]
[3]. Hong Q, Lebrilla CB, Miyamoto S, et al.. Absolute quantitation of immunoglobulin G and its glycoforms using multiple reaction monitoring. Analytical chemistry. 2013 Sep 17;85(18):8585-93. [Content Brief]
[4]. Kleinberg A, Yoon J, Mao Y, et al.. Eliminating liquid chromatography-induced methionine oxidation of monoclonal antibodies using high-concentration TCEP injections: The "anTCEPtic" column cleaning method. Journal of pharmaceutical sciences. 2026 Jun;115(6):104298. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DTLMISR Related Classifications
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