EEF1A2-IN-1
EEF1A2-IN-1 is a potent and covalen EEF1A2 inhibitor. EEF1A2-IN-1 exhibits selective antiproliferative activity against osteosarcoma (OS) cells. EEF1A2-IN-1 induces apoptosis by inhibiting EEF1A2 and downregulating the AKT signaling pathway. EEF1A2-IN-1 inhibits tumor growth in a xenograft mouse model. EEF1A2-IN-1 can be used for the research of OS.
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- Formule: C18H17NO4
- Masse moléculaire:311.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
EEF1A2-IN-1 (compound 8e) (24-72 h) exhibits potent antiproliferative\ractivity against various cell lines, with IC50 values of 0.73 (143B), 2.27 (SJSA-1), 4.34 (MG63), 2.47 (MNNG/HOS), 7.25 (U2OS), 1.93 (HOS), 4.84 (A549), and 9.59 μM (BMSC), respectively[1].
EEF1A2-IN-1 (96 h-10 days) inhibits colony formation of 143B cells in an EEF1A2-dependent manner, also inhibits the proliferation of 143B cells, si-EEF1A2-2 cells, and OE-EEF1A2 143B cells with IC50 values of 0.73, 2.78, and 0.19 μM, respectively, indicating that EEF1A2 is essential for the proliferation and migration of OS 143B cells[1].
EEF1A2-IN-1 (0-3 μM, 0-24 h) effectively inhibits the migration of 143B cells[1].
EEF1A2-IN-1 (0-3 μM) effectively inhibits the invasion of 143B cells[1].
EEF1A2-IN-1 (0-3 μM) induces apoptosis in 143B cells by inhibiting its target EEF1A2, which results in the downregulation of both the Nogo-B protein and the AKT signaling pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:143B cells
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Concentration:0, 0.3, 1, 3 μM
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Incubation Time:0, 24 h
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Result:Revealed a significant decrease in the percentage of intercellular wound healing distance.
Inhibited the migration of 143B cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Balb/c nude mice (3 months old) subcutaneously injected with 143B cells[1]
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Dosage:20 mg/kg
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Administration:i.p., daily for 15 days
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Result:Significantly suppressed OS tumor growth, with tumor growth inhibition (TGI) rates of 30.1%.
Showed no significant change in bodyweight.
Exhibited no discernible morphological changes in the heart, liver, spleen, or kidney tissues.
Chemical Information
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Masse moléculaire 311.33
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Formule C18H17NO4
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SMILES
C=CC(NC(C1=CC=C(C=C1)C2=CC=C(C=C2)O)C(OC)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EEF1A2-IN-1 Related Classifications
HY-179370 Related Classifications
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