Fostroxacitabine bralpamide
Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide proagent. Fostroxacitabine bralpamide has anticancer effects.
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- CAS No.: 2129993-56-0
- Formule: C22H30BrN4O8P
- Masse moléculaire:589.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Fostroxacitabine bralpamide (MIV-818) is highly metabolized by human hepatocytes, directing high levels of the chain-terminating nucleotide tri-phosphate to the liver. The tri-phosphate is incorporated into DNA during replication, which leads to DNA double strand breaks, DNA damage responses, and cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2129993-56-0
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Masse moléculaire 589.37
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Formule C22H30BrN4O8P
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SMILES
O=C1N([C@H](CO2)O[C@H]2CO[P@](OC(C=C3)=CC=C3Br)(N[C@@H](C)C(O[C@@H](C)CCC)=O)=O)C=CC(N)=N1
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Synonyms
MIV-818
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fostroxacitabine bralpamide Related Classifications
HY-132815 Related Classifications
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