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KLF2 - KLF transcription factor 2 Gene

Also Known as LKLF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10365

About KLF2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,324,826-16,328,685 (from NCBI)

This gene has 2 transcripts (splice variants), 102 orthologues and 22 paralogues. Broad expression in fat (RPKM 40.2), ovary (RPKM 23.1) and 19 other tissues.

Summary

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded Zinc Finger Protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]

KLF2 Products (1)

mRNA	Protein	Name
NM_016270.4	NP_057354.1	Krueppel-like factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	22327366	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	21063504	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	22327366	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16617118	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cellular response to fluid shear stress	IMP IMP: Inferred from mutant phenotype	22327366	GOA
involved in cellular response to laminar fluid shear stress	IMP IMP: Inferred from mutant phenotype	23043106	GOA
involved in cellular stress response to acid chemical	IMP IMP: Inferred from mutant phenotype	26299712	GOA
involved in negative regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	26299712	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	26299712	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21063504	GOA
acts upstream of positive regulation of nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	21768538	GOA
involved in positive regulation of protein metabolic process	IGI IGI: Inferred from genetic interaction	20551324	GOA
involved in positive regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	26416422	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20551324	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22327366	GOA
acts upstream of vasodilation	IMP IMP: Inferred from mutant phenotype	21768538	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in chromatin	IMP IMP: Inferred from mutant phenotype	22327366	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLF2 Protein Structure

zf-H2C2_2

0
100
200
300
355 a.a.

Protein Preferred Names	Protein Names
Krueppel-like factor 2	Kruppel like factor 2

KLF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	KLF2	Q9Y5W3	KAT2B	Homo sapiens	Q92831	Pull Down	16617118
Intra	KLF2	Q9Y5W3	KAT2B	Homo sapiens	Q92831	Anti Tag CoIP	16617118
Intra	KLF2	Q9Y5W3	SMURF1	Homo sapiens	Q9HCE7	Anti Tag CoIP	21382345
Intra	KLF2	Q9Y5W3	SMURF1	Homo sapiens	Q9HCE7-2	Anti Tag CoIP	21382345

Cross: Cross-species interaction Intra: Intraspecies interaction

KLF2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P84897	KLF2 Antibody (YA4594)	WB, ELISA	Human, Mouse
HY-P84897A	KLF2 Antibody (YA4594)(PBS only)	WB, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Spleen Cancer	Spleen Neoplasm Splenic Neoplasm Splenic Neoplasms Malignant Splenic Tumor Malignant Tumour Of Spleen Tumor Of Spleen Malignant Neoplasm Of Spleen
Splenic Marginal Zone Lymphoma	Smzl Splenic Marginal Zone B-Cell Lymphoma
Cerebrocostomandibular Syndrome	Cerebro-Costo-Mandibular Syndrome CCMS Rib Gap Defects With Micrognathia Ccm Syndrome
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS17539	Klf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23996	Klf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N18377	Moldapyranone A	Activator	/	Unkown
HY-RS07339	KLF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KLF2	VGNC	VGNC:102626
Mus musculus	KLF2	MGD	MGI:1342772
Rattus norvegicus	KLF2	RGD	RGD:1359220
Bos taurus	KLF2	VGNC	VGNC:106799
Others	KLF2	NCBI