Sqstm1 - sequestosome 1 Gene

Also Known as Osi; p62; A170; STAP; OSF-6; STONE14

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18412

Summary

Enables K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including brown fat cell proliferation; energy homeostasis; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in GNE myopathy; Paget's disease of bone; and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Apr 2022]

Sqstm1 Products (2)

mRNA Protein Name
NM_001290769.1 NP_001277698.1 sequestosome-1 isoform 2
NM_011018.3 NP_035148.1 sequestosome-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables K63-linked polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
16252010 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
21220506 MGI
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
19004011 MGI
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
33397898 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
33397898 MGI
enables ubiquitin-modified protein reader activity IDA
IDA: Inferred from direct assay
25723488 MGI
Biological Process GO Annotation Evidence Références Source
involved in aggrephagy IDA
IDA: Inferred from direct assay
25723488 MGI
involved in autophagy IDA
IDA: Inferred from direct assay
20173742 MGI
involved in brown fat cell proliferation IMP
IMP: Inferred from mutant phenotype
32385399 MGI
involved in energy homeostasis IMP
IMP: Inferred from mutant phenotype
32385399 MGI
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
20173742 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24035364 MGI
involved in non-membrane-bounded organelle assembly IDA
IDA: Inferred from direct assay
33397898 MGI
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
19004011 MGI
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
19004011 MGI
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
32385399 MGI
involved in protein import into nucleus IMP
IMP: Inferred from mutant phenotype
32385399 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
32385399 MGI
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
32385399 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24035364 MGI
Cellular Component GO Annotation Evidence Références Source
located in aggresome IDA
IDA: Inferred from direct assay
22792322 MGI
located in autolysosome IDA
IDA: Inferred from direct assay
26284655 MGI
located in autophagosome IDA
IDA: Inferred from direct assay
24713655 MGI
is active in intracellular non-membrane-bounded organelle IDA
IDA: Inferred from direct assay
33397898 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
32047033 MGI
located in phagophore assembly site IDA
IDA: Inferred from direct assay
21220506 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
22033522 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sequestosome-1

  • oxidative stress induced

  • ubiquitin-binding protein p62

Sqstm1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Sqstm1 Q64337 MAP1LC3B Homo sapiens Q9GZQ8
Anti Tag CoIP
19250911
Intra
Sqstm1 Q64337 Keap1 Mus musculus Q9Z2X8
Pull Down
20173742
Intra
Sqstm1 Q64337 Keap1 Mus musculus Q9Z2X8
Anti Tag CoIP
20173742
Cross
Sqstm1 Q64337 KEAP1 Homo sapiens Q14145
Anti Tag CoIP
20173742
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-112698 CA-5f 99.14% Unkown
HY-117469 Triptohypol C 96.56% Unkown
HY-161746 Anle138b-F105 Inducer 98.59% Unkown
HY-RS13745 SQSTM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-152100 CUR5g Inhibitor 98.69% Unkown
HY-169387 YT 6-2-PEG3-C2-NH2 Control 99.50% Unkown
HY-169385 ATC-324 Degrader / Unkown
HY-169386 YT 6-2 analog-1 Control / Unkown
HY-169388 YT 6-2 Control / Unkown
HY-184089 ATB1071 / Unkown
HY-184160 Mcl1 Degrader-1 / Unkown
HY-RS17351 Sqstm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23805 Sqstm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sqstm1 NCBI NCBI:8878