Trpc5 - transient receptor potential cation channel, subfamily C, member 5 Gene

Also Known as CCE2; TRP5; TRP-5; Trrp5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22067

Summary

Enables inositol 1,4,5 trisphosphate binding activity. Involved in neuron apoptotic process and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Predicted to be part of Calcium Channel complex. Predicted to be integral component of plasma membrane. Is expressed in brain; cochlea; dorsal root ganglion; and vagus ganglion. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Apr 2022]

Trpc5 Products (1)

mRNA Protein Name
NM_009428.3 NP_033454.1 short transient receptor potential channel 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables inositol 1,4,5 trisphosphate binding IDA
IDA: Inferred from direct assay
14505576 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14505576 MGI
Biological Process GO Annotation Evidence Références Source
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
32110987 MGI
involved in phosphatidylserine exposure on apoptotic cell surface IMP
IMP: Inferred from mutant phenotype
32110987 MGI
Cellular Component GO Annotation Evidence Références Source
is active in presynapse IDA
IDA: Inferred from direct assay
17928293 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

short transient receptor potential channel 5

  • capacitative calcium entry channel 2

  • transient receptor protein 5

  • trp-related protein 5

  • vtransient receptor potential cation channel, subfamily C, member 5

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-17386 Rosiglitazone Modulator 99.94% Yes
HY-17386A Rosiglitazone hydrochloride Modulator 99.81% Yes
HY-30234A Clemizole hydrochloride Inhibitor 99.99% Yes
HY-30234 Clemizole Inhibitor 98.42% Yes
HY-17386B Rosiglitazone potassium Modulator 99.13% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-162584 TRPC5-IN-6 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-133168 Englerin A Activator 99.50% Unkown
HY-12949 ML204 Inhibitor 98.45% Unkown
HY-12949A ML204 hydrochloride Inhibitor 99.74% Unkown
HY-30234S Clemizole-d4 Inhibitor 99.82% Unkown
HY-N2595 Oxoglaucine Inhibitor / Unkown
HY-184164 JD03-02 Antagonist / Unkown
HY-173024 TRPC4/5-IN-3 Inhibitor 99.65% Unkown
HY-146155 TRPC4/5-IN-1 Inhibitor / Unkown
HY-144429 TRPC5-IN-4 Inhibitor / Unkown
HY-162090 TRPC antagonist 1 Antagonist / Unkown
HY-172106 TRPC5-IN-5 Inhibitor / Unkown
HY-18101 BD-1063 Inhibitor / Unkown
HY-30234B Clemizole sulfate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpc5 NCBI NCBI:7224