PIDD1 - p53-induced death domain protein 1 Gene

Also Known as LRDD; PIDD; MRT75

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55367

About PIDD1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:799,184-809,501 (from NCBI)

This gene has 11 transcripts (splice variants), 116 orthologues, 31 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 3.7), spleen (RPKM 3.6) and 25 other tissues.

Summary

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with Other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell Apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

PIDD1 Products (2)

mRNA Protein Name
NM_145886.4 NP_665893.2 p53-induced death domain-containing protein 1 isoform 1
NM_145887.4 NP_665894.2 p53-induced death domain-containing protein 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
17159900 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15073321 GOA
Biological Process GO Annotation Evidence Références Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
21726810 GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
IMP: Inferred from mutant phenotype
21726810 GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
17159900 GOA
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
17159900 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21726810 GOA
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
17159900 GOA
involved in regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
17159900 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17159900 GOA
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
21726810 GOA
part of endopeptidase complex IPI
IPI: Inferred from physical interaction
15073321 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17159900 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
21726810 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIDD1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (126 - 183)

LRR_8

LRR_8: Leucine rich repeat (195 - 252)

LRR_1

LRR_1: Leucine Rich Repeat (265 - 283)

ZU5

ZU5: ZU5 domain (339 - 416)

Peptidase_S68

Peptidase_S68: Peptidase S68 (421 - 454)

ZU5

ZU5: ZU5 domain (469 - 537)

Death

Death: Death domain (796 - 871)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 910 a.a.
Protein Preferred Names Protein Names

p53-induced death domain-containing protein 1

  • leucine-rich repeat and death domain-containing protein

PIDD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PIDD1 Q9HB75 CRADD Homo sapiens P78560
Anti Tag CoIP
15073321
Intra
PIDD1 Q9HB75 CRADD Homo sapiens P78560
IF
16652156
Intra
PIDD1 Q9HB75 CRADD Homo sapiens P78560
Anti Tag CoIP
17159900
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly

  • MRT75
Megalencephaly

  • Macroencephaly

  • Macrencephaly
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS10481 PIDD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21689 Pidd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28207 Pidd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PIDD1 VGNC VGNC:81498
Rattus norvegicus PIDD1 RGD RGD:1311792
Mus musculus PIDD1 MGD MGI:1889507
Canis familiaris PIDD1 VGNC VGNC:44527
Bos taurus PIDD1 VGNC VGNC:32863
Felis catus PIDD1 VGNC VGNC:81960
Others PIDD1 NCBI