Dbn1 - drebrin 1 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56320

Summary

Predicted to enable actin filament binding activity; cytoskeletal motor inhibitor activity; and profilin binding activity. Involved in positive regulation of dendritic spine morphogenesis; positive regulation of receptor localization to synapse; and positive regulation of synaptic plasticity. Acts upstream of or within several processes, including cell communication by chemical coupling; cell communication by electrical coupling; and maintenance of protein location in cell. Located in several cellular components, including gap junction; glutamatergic synapse; and postsynaptic density. Is active in postsynaptic cytosol and postsynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and retina. Orthologous to human DBN1 (drebrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Dbn1 Products (3)

mRNA	Protein	Name
NM_001177371.1	NP_001170842.1	drebrin isoform 1
NM_001177372.1	NP_001170843.1	drebrin isoform 2
NM_019813.4	NP_062787.2	drebrin isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15084279	MGI

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within actin filament organization	IDA IDA: Inferred from direct assay	11991718	MGI
acts upstream of or within cell communication by chemical coupling	IMP IMP: Inferred from mutant phenotype	15084279	MGI
acts upstream of or within cell communication by electrical coupling	IMP IMP: Inferred from mutant phenotype	15084279	MGI
involved in generation of neurons	IEP IEP: Inferred from expression pattern	20882566	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	27996060	MGI
acts upstream of or within maintenance of protein location in cell	IMP IMP: Inferred from mutant phenotype	15084279	MGI
involved in neural precursor cell proliferation	IEP IEP: Inferred from expression pattern	20882566	MGI
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	25865831	MGI
involved in positive regulation of receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	25865831	MGI
involved in positive regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	25865831	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	11991718	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	15084279	MGI
located in gap junction	IDA IDA: Inferred from direct assay	15084279	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17559090	MGI
located in growth cone	IDA IDA: Inferred from direct assay	24720729	MGI
located in membrane	IDA IDA: Inferred from direct assay	15084279	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15084279	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	17559090	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	17559090	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	17559090	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
drebrin	developmentally-regulated brain protein drebrin A drebrin E2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS03548	DBN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21320	Dbn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27839	Dbn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dbn1	NCBI	NCBI:1627