Smyd3 - SET and MYND domain containing 3 Gene

Also Known as Zmynd1; 2410008A19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 69726

About Smyd3

Chromosome 1: 178,779,525-179,345,606 reverse strand.GRCm39:CM000994.3

This gene has 7 transcripts (splice variants), 231 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in CNS E18 (RPKM 2.4), cerebellum adult (RPKM 2.2) and 28 other tissues.

Summary

Enables RNA polymerase II complex binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and histone-lysine N-methyltransferase activity. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; nucleosome assembly; and regulation of protein phosphorylation. Located in nucleus. Is expressed in brain; embryo; metanephros; ovary; and thymus. Orthologous to human SMYD3 (SET and MYND domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Smyd3 Products (2)

mRNA	Protein	Name
NM_027188.4	NP_081464.1	histone-lysine N-methyltransferase SMYD3
NM_027188.4	NP_081464.1	histone-lysine N-methyltransferase SMYD3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23752591	MGI
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	23752591	MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23752591	MGI
enables histone H3K36 dimethyltransferase activity	IDA IDA: Inferred from direct assay	16805913	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23752591	MGI

Biological Process GO Annotation	Evidence	Références	Source
acts upstream of or within cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	23752591	MGI
acts upstream of or within establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within myotube cell development	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within nucleosome assembly	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23752591	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23752591	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleus	IDA IDA: Inferred from direct assay	23752591	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Smyd3 Protein Structure

SET_SMYD3

zf-MYND

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
histone-lysine N-methyltransferase SMYD3	SET and MYND domain-containing protein 3 zinc finger MYND domain-containing protein 1 zinc finger, MYND domain containing 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-19324	EPZ031686	Inhibitor	99.71%	Unkown
HY-21972	BCI-121	Inhibitor	99.89%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-112080	BAY-6035	Inhibitor	99.51%	Unkown
HY-151379	EM127	Inhibitor	99.94%	Unkown
HY-104009A	GSK2807 Trifluoroacetate	Inhibitor	99.83%	Unkown
HY-128352	SMYD3-IN-1	Inhibitor	98.03%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-152228	SMYD3-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smyd3	NCBI	NCBI:64754