SMYD3 - SET and MYND domain containing 3 Gene

Also Known as KMT3E; ZMYND1; ZNFN3A1; bA74P14.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64754

About SMYD3

Cytogenetic location: 1q44 Genomic coordinates (GRCh38): 1:245,749,347-246,507,279 (from NCBI)

This gene has 18 transcripts (splice variants), 231 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 1.8), brain (RPKM 1.2) and 25 other tissues.

Summary

This gene encodes a Histone Methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

SMYD3 Products (19)

mRNA Protein Name
XM_047428021.1 XP_047283977.1 histone-lysine N-methyltransferase SMYD3 isoform X2
NM_001375962.1 NP_001362891.1 histone-lysine N-methyltransferase SMYD3 isoform 3
XM_024449136.2 XP_024304904.1 histone-lysine N-methyltransferase SMYD3 isoform X2
NM_001375966.1 NP_001362895.1 histone-lysine N-methyltransferase SMYD3 isoform 5
XM_011544259.4 XP_011542561.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_024449149.2 XP_024304917.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_011544257.2 XP_011542559.1 histone-lysine N-methyltransferase SMYD3 isoform X4
XM_017002094.3 XP_016857583.1 histone-lysine N-methyltransferase SMYD3 isoform X5
NM_001375965.1 NP_001362894.1 histone-lysine N-methyltransferase SMYD3 isoform 4
XM_047428019.1 XP_047283975.1 histone-lysine N-methyltransferase SMYD3 isoform X1
XM_047428020.1 XP_047283976.1 histone-lysine N-methyltransferase SMYD3 isoform X2
NM_001167740.2 NP_001161212.1 histone-lysine N-methyltransferase SMYD3 isoform 1
NM_022743.3 NP_073580.1 histone-lysine N-methyltransferase SMYD3 isoform 2
XM_024449162.2 XP_024304930.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_047428022.1 XP_047283978.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_024449141.2 XP_024304909.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_011544254.3 XP_011542556.1 histone-lysine N-methyltransferase SMYD3 isoform X3
NM_001375963.1 NP_001362892.1 histone-lysine N-methyltransferase SMYD3 isoform 2
XM_011544261.4 XP_011542563.1 histone-lysine N-methyltransferase SMYD3 isoform X5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H4 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
25738358 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25738358 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
25738358 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMYD3 Protein Structure

zf-MYND

zf-MYND: MYND finger (2 - 28)

SET

SET: SET domain (79 - 180)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SMYD3

  • SET and MYND domain-containing protein 3

  • zinc finger MYND domain-containing protein 1

  • zinc finger protein, subfamily 3A (MYND domain containing), 1

  • zinc finger, MYND domain containing 1

SMYD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SMYD3 Q9H7B4 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SMYD3 Proteins

Cat. No. Product Name Accession Purity
HY-P76080 SMYD3 Protein, Human (sf9, GST) Q9H7B4-3 (K35-S369) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P700258 SMYD3 Protein, Human (His-Myc) Q9H7B4-1 (M1-S428) ≥ 90%, as determined by reducing SDS-PAGE.

SMYD3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82258 SMYD3 Antibody (YA2003) WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P82258A SMYD3 Antibody (YA2003)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19324 EPZ031686 Inhibitor 99.71% Unkown
HY-21972 BCI-121 Inhibitor 99.89% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-112080 BAY-6035 Inhibitor 99.51% Unkown
HY-151379 EM127 Inhibitor 99.94% Unkown
HY-104009A GSK2807 Trifluoroacetate Inhibitor 99.83% Unkown
HY-128352 SMYD3-IN-1 Inhibitor 98.03% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152228 SMYD3-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SMYD3 MGD MGI:1916976
Macaca mulatta SMYD3 VGNC VGNC:77713
Rattus norvegicus SMYD3 RGD RGD:1562635
Bos taurus SMYD3 VGNC VGNC:35044
Felis catus SMYD3 VGNC VGNC:107943
Others SMYD3 NCBI