1. Epigenetics
  2. Histone Methyltransferase
  3. BAY-6035

BAY-6035 

Cat. No.: HY-112080
Handling Instructions

BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM.

For research use only. We do not sell to patients.

BAY-6035 Chemical Structure

BAY-6035 Chemical Structure

CAS No. : 2247890-13-5

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Description

BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM[1].

IC50 & Target[1]

SMYD3

88 nM (IC50)

In Vitro

BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC50 of 88 nM and has more than 100-fold selectivity over other histone methyltransferases[1].
BAY-6035 inhibits the methylation of MEKK2 in cells with an IC50 of 70 nM[1].

Molecular Weight

396.48

Formula

C₂₂H₂₈N₄O₃

CAS No.

2247890-13-5

SMILES

O=C1C[[email protected]](C)N(C(N2CC(C3)C3C2)=O)C4=CC=C(C(NCCC5CC5)=O)C=C4N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BAY-6035BAY6035BAY 6035Histone MethyltransferaseSMYD3methylationMEKK2Inhibitorinhibitorinhibit

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