2. Epigenetics
  3. Histone Methyltransferase
  4. SMYD3-IN-1

SMYD3-IN-1 (compound 29) is an irreversible and selective inhibitor of SMYD3 (SET and MYND domain containing 3), with an IC50 of 11.7 nM.

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SMYD3-IN-1 Chemical Structure

SMYD3-IN-1 Chemical Structure

CAS No. : 2095160-79-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 480 In-stock
Solution
10 mM * 1 mL in DMSO USD 480 In-stock
Solid
5 mg USD 430 In-stock
10 mg USD 700 In-stock
25 mg USD 1400 In-stock
50 mg USD 2300 In-stock
100 mg USD 3700 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SMYD3-IN-1 (compound 29) is an irreversible and selective inhibitor of SMYD3 (SET and MYND domain containing 3), with an IC50 of 11.7 nM[1].

IC50 & Target[1]

SMYD3

11.7 nM (IC50)

Molecular Weight

507.02

Formula

C28H31ClN4O3
CAS No.
Appearance

Solid

SMILES

O=C(N1[C@H](C)CN(C(C2=CC=C3C(Cl)=CC(C4=CC=C(C5(N)CC5)C=C4)=NC3=C2)=O)CC1)OCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (197.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9723 mL 9.8615 mL 19.7231 mL
5 mM 0.3945 mL 1.9723 mL 3.9446 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9723 mL 9.8615 mL 19.7231 mL 49.3077 mL
5 mM 0.3945 mL 1.9723 mL 3.9446 mL 9.8615 mL
10 mM 0.1972 mL 0.9862 mL 1.9723 mL 4.9308 mL
15 mM 0.1315 mL 0.6574 mL 1.3149 mL 3.2872 mL
20 mM 0.0986 mL 0.4931 mL 0.9862 mL 2.4654 mL
25 mM 0.0789 mL 0.3945 mL 0.7889 mL 1.9723 mL
30 mM 0.0657 mL 0.3287 mL 0.6574 mL 1.6436 mL
40 mM 0.0493 mL 0.2465 mL 0.4931 mL 1.2327 mL
50 mM 0.0394 mL 0.1972 mL 0.3945 mL 0.9862 mL
60 mM 0.0329 mL 0.1644 mL 0.3287 mL 0.8218 mL
80 mM 0.0247 mL 0.1233 mL 0.2465 mL 0.6163 mL
100 mM 0.0197 mL 0.0986 mL 0.1972 mL 0.4931 mL
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SMYD3-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMYD3-IN-12095160-79-3Histone MethyltransferaseInhibitorinhibitorinhibit

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