SMYD3-IN-1
Based on 1 Customer Validation
SMYD3-IN-1 (compound 29) is an irreversible and selective inhibitor of SMYD3 (SET and MYND domain containing 3), with an IC50 of 11.7 nM.
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- Pureté : 98.03%
- CAS No.: 2095160-79-3
- Formule: C28H31ClN4O3
- Masse moléculaire:507.02
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
SMYD3 11.7 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | GI50 |
1.04 μM
Compound: 29
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Inhibition of SMYD3 in human HepG2 cells assessed as inhibition of anchorage-independent colony formation in 3D culture cells incubated for 1 to 2 weeks by thiazolyl blue tetrazolium bromide based
Inhibition of SMYD3 in human HepG2 cells assessed as inhibition of anchorage-independent colony formation in 3D culture cells incubated for 1 to 2 weeks by thiazolyl blue tetrazolium bromide based
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[PMID: 31223458] |
| HepG2 | GI50 |
17.69 μM
Compound: 29
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Inhibition of SMYD3 in human HepG2 cells assessed as inhibition of cell proliferation incubated for 3 days by CellTiter-Glo luminescent assay
Inhibition of SMYD3 in human HepG2 cells assessed as inhibition of cell proliferation incubated for 3 days by CellTiter-Glo luminescent assay
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[PMID: 31223458] |
Chemical Information
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CAS No. 2095160-79-3
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Appearance Solid
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Masse moléculaire 507.02
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Formule C28H31ClN4O3
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Color Off-white to pink
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SMILES
O=C(N1[C@H](C)CN(C(C2=CC=C3C(Cl)=CC(C4=CC=C(C5(N)CC5)C=C4)=NC3=C2)=O)CC1)OCCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (197.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
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Fiche technique (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9723 mL | 9.8615 mL | 19.7231 mL | 49.3077 mL |
| 5 mM | 0.3945 mL | 1.9723 mL | 3.9446 mL | 9.8615 mL | |
| 10 mM | 0.1972 mL | 0.9862 mL | 1.9723 mL | 4.9308 mL | |
| 15 mM | 0.1315 mL | 0.6574 mL | 1.3149 mL | 3.2872 mL | |
| 20 mM | 0.0986 mL | 0.4931 mL | 0.9862 mL | 2.4654 mL | |
| 25 mM | 0.0789 mL | 0.3945 mL | 0.7889 mL | 1.9723 mL | |
| 30 mM | 0.0657 mL | 0.3287 mL | 0.6574 mL | 1.6436 mL | |
| 40 mM | 0.0493 mL | 0.2465 mL | 0.4931 mL | 1.2327 mL | |
| 50 mM | 0.0394 mL | 0.1972 mL | 0.3945 mL | 0.9862 mL | |
| 60 mM | 0.0329 mL | 0.1644 mL | 0.3287 mL | 0.8218 mL | |
| 80 mM | 0.0247 mL | 0.1233 mL | 0.2465 mL | 0.6163 mL | |
| 100 mM | 0.0197 mL | 0.0986 mL | 0.1972 mL | 0.4931 mL |
SMYD3-IN-1 Related Classifications
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