1. Epigenetics
  2. Histone Methyltransferase
  3. EPZ031686

EPZ031686 

Cat. No.: HY-19324 Purity: 99.82%
Handling Instructions

EPZ031686 is an orally available SMYD3 inhibitor with an IC50 of 3 nM in cell-free assay.

For research use only. We do not sell to patients.

EPZ031686 Chemical Structure

EPZ031686 Chemical Structure

CAS No. : 1808011-22-4

Size Price Stock Quantity
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    EPZ031686 purchased from MCE. Usage Cited in: Aging. 2020 Nov 3;12(21):21423-21445.

    EPZ031686 (20 μM) reverses Ang II-induced PARP16 and RAECs senescence. Inhibition of Smyd3 could downregulate protein level of PARP16, together with reduced ER stress and senescence markers.
    • Biological Activity

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    • References

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    Description

    EPZ031686 is an orally available SMYD3 inhibitor with an IC50 of 3 nM in cell-free assay.

    Molecular Weight

    591.09

    Formula

    C₂₆H₃₄ClF₃N₄O₄S

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 5.9 mg/mL (9.98 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6918 mL 8.4589 mL 16.9179 mL
    5 mM 0.3384 mL 1.6918 mL 3.3836 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  30% PEG300  70% (20% SBE-β-CD in saline)

      Solubility: 10 mg/mL (16.92 mM); Suspended solution; Need ultrasonic and warming

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.82%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    EPZ031686
    Cat. No.:
    HY-19324
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